2024-03-29T05:47:32Z
https://zenodo.org/oai2d
oai:zenodo.org:168393
2020-01-20T17:27:12Z
user-fp7postgrantoapilotoutputs
user-eu
Avellana, Narcís (ed.)
Fernández, Alberto (ed.)
2016-11-21
<p><em>iURBAN: Intelligent Urban Energy</em> Tool introduces an urban energy tool integrating different ICT energy management systems (both hardware and software) in two European cities, providing useful data to a novel decision support system that makes available the necessary parameters for the generation and further operation of associated business models. The business models contribute at a global level to efficiently manage and distribute the energy produced and consumed at a local level (city or neighbourhood), incorporating behavioural aspects of the users into the software platform and in general prosumers. <br>
<br>
iURBAN integrates a smart Decision Support System (smartDSS) that collects real-time or near real-time data, aggregates, analyses and suggest actions of energy consumption and production from different buildings, renewable energy production resources, combined heat and power plants, electric vehicles (EV) charge stations, storage systems, sensors and actuators. The consumption and production data is collected via a heterogeneous data communication protocols and networks. The iURBAN smartDSS through a Local Decision Support System allows the citizens to analyse the consumptions and productions that they are generating, receive information about CO2 savings, advises in demand response and the possibility to participate actively in the energy market. Whilst, through a Centralised Decision Support System allow to utilities, ESCOs, municipalities or other authorised third parties to: </p>
<ul>
<li>Get a continuous snapshot of city energy consumption and production</li>
<li>Manage energy consumption and production</li>
<li>Forecasting of energy consumption</li>
<li>Planning of new energy "producers" for the future needs of the city</li>
</ul>
<p><br>
Visualise, analyse and take decisions of all the end points that are consuming or producing energy in a city level, permitting them to forecast and planning renewable power generation available in the city.</p>
EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519091
oai:zenodo.org:168393
River Publishers
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
renewable energy
ICT energy management systems
urban energy
sustainability
iURBAN
iURBAN: Intelligent Urban Energy Tool
info:eu-repo/semantics/book
oai:zenodo.org:44954
2020-01-20T15:27:34Z
user-fp7postgrantoapilotoutputs
user-eu
Oo, S.Z.
Siitonen, S.
Kontturi, V.
Eustace, D.A.
Charlton, M.D.B.
2016-01-08
<p>In this paper we investigate suitability of arrays of gold coated pyramids for surface-enhanced Raman scattering (SERS) sensing applications. Pyramidarrays composed of 1000nm pit size with 1250nm pitch lengthwerereplicated on a plastic substrate by roll-to-roll (R2R) ultraviolet (UV) embossing. The level of SERS enhancement, and qualitative performance provided by the new substrate is investigated by comparing Raman spectrum of benzenethiol (BTh) test molecules to the benchmark Klarite SERS substrate which comprises inverted pyramid arrays(1500nm pit size with 2000nm pitch length) fabricated on a silicon substrate. The new substrate is found to provide upto 11 times increase in signal in comparison to the inverted pyramid (IV-pyramid) arrays fabricated on an identical plastic substrate. Numerical simulation and experimental evidence suggest that strongly confined electromagnetic fields close to the base of the pyramids, are mainly responsible for the Raman enhancement factor, instead of the fields localized around the tip. Unusually strong plasmon fields are projected upto 200nm from the sidewalls at the base of the pyramid increasing the cross sectional sensing volume.</p>
USD 1,849 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1364/OE.24.000724
oai:zenodo.org:44954
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Optics Express, 24(1), 724-731, (2016-01-08)
(240.6695) Surface-enhanced Raman scattering
(130.6010) Sensors
(250.5403) Plasmonics
Disposable gold coated pyramidal SERS sensor on the plastic platform
info:eu-repo/semantics/article
oai:zenodo.org:33736
2020-01-20T15:26:56Z
user-fp7postgrantoapilotoutputs
user-eu
Mellendijk, Laura
Wiesmann, Maximilian
Kiliaan, Amanda J.
2015-11-13
<p>The increasing prevalence of Metabolic Syndrome (MetS), defined as the clustering of abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, appears to be driving the global epidemics cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Nutrition has a major impact on MetS and plays an important role in the prevention, development, and treatment of its features. Structural and functional alterations in the vasculature, associated with MetS, might form the link between MetS and the increased risk of developing CVD and T2DM. Not only does the peripheral vasculature seem to be affected, but the syndrome has a profound impact on the cerebral circulation and thence brain structure as well. Furthermore, strong associations are shown with stroke, cognitive impairment, and dementia. In this review the impact of nutrition on the individual components of MetS, the effects of MetS on peripheral and cerebral vasculature, and its consequences for brain structure and function will be discussed.</p>
CHF 1400 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3390/nu7115477
oai:zenodo.org:33736
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Metabolic Syndrome
Nutrition
Obesity
Dyslipidemia
Hypertension
Hyperglycemia
cerebral circulation
Cognition
dementia
Impact of Nutrition on Cerebral Circulation and Cognition in the Metabolic Syndrome
info:eu-repo/semantics/article
oai:zenodo.org:45455
2020-01-20T15:27:19Z
user-fp7postgrantoapilotoutputs
user-eu
Stok, F. Marijn
De Ridder, Denise T. D.
De Vet, Emely
Nureeva, Liliya
Luszczynska, Aleksandra
Wardle, Jane
Gaspar, Tania
De Wit, John B. F.
2016-01-05
<p><strong>Background</strong></p>
<p>Effective interventions promoting healthier eating behavior among adolescents are urgently needed. One factor that has been shown to impact effectiveness is whether the target population accepts the intervention. While previous research has assessed adults’ acceptance of eating-related interventions, research on the opinion of adolescents is lacking. The current study addressed this gap in the literature.</p>
<p><strong>Methods</strong></p>
<p>Two thousand seven hundred sixty four adolescents (aged 10–17 years) from four European countries answered questions about individual characteristics (socio-demographics, anthropometrics, and average daily intake of healthy and unhealthy foods) and the acceptability of ten eating-related intervention strategies. These strategies varied in type (either promoting healthy eating or discouraging unhealthy eating), level of intrusiveness, setting (home, school, broader out-of-home environment), and change agent (parents, teacher, policy makers).</p>
<p><strong>Results</strong></p>
<p>Based on adolescents’ acceptability ratings, strategies could be clustered into two categories, those promoting healthy eating and those discouraging unhealthy eating, with acceptability rated significantly higher for the former. Acceptability of intervention strategies was rated moderate on average, but higher among girls, younger, overweight and immigrant adolescents, and those reporting healthier eating. Polish and Portuguese adolescents were overall more accepting of strategies than UK and Dutch adolescents.</p>
<p><strong>Conclusions</strong></p>
<p>Adolescents preferred intervention strategies that promote healthy eating over strategies that discourage unhealthy eating. Level of intrusiveness affected acceptability ratings for the latter type of strategies only. Various individual and behavioral characteristics were associated with acceptability. These findings provide practical guidance for the selection of acceptable intervention strategies to improve adolescents’ eating behavior.</p>
EUR 1,800 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1186/s12889-015-2665-6
oai:zenodo.org:45455
https://pubmed.ncbi.nlm.nih.gov/26729328
https://www.ncbi.nlm.nih.gov/pmc/PMC4700578
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
BMC Public Health, 16(5), (2016-01-05)
Overweight
Eating behavior
Adolescents
Prevention
Interventions
Public policy
Hungry for an intervention? Adolescents’ ratings of acceptability of eating-related intervention strategies
info:eu-repo/semantics/article
oai:zenodo.org:44600
2020-01-20T15:26:40Z
user-fp7postgrantoapilotoutputs
user-eu
Fernández, Roemi
Montes, Héctor
Salinas, Carlota
2015-06-15
<p>Ground bearing capacity has become a relevant concept for site-specific management that aims to protect soil from the compaction and the rutting produced by the indiscriminate use of agricultural and forestry machines. Nevertheless, commonly known techniques for its estimation are cumbersome and time-consuming. In order to alleviate these difficulties, this paper introduces an innovative sensory system based on Visible-Near InfraRed (VIS-NIR), Short-Wave InfraRed (SWIR) and Long-Wave InfraRed (LWIR) imagery and a sequential algorithm that combines a registration procedure, a multi-class SVM classifier, a K-means clustering and a linear regression for estimating the ground bearing capacity. To evaluate the feasibility and capabilities of the presented approach, several experimental tests were carried out in a sandy-loam terrain. The proposed solution offers notable benefits such as its non-invasiveness to the soil, its spatial coverage without the need for exhaustive manual measurements and its real time operation. Therefore, it can be very useful in decision making processes that tend to reduce ground damage during agricultural and forestry operations.</p>
CHF 1,620 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3390/s150613994
oai:zenodo.org:44600
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Sensors, (2015-06-15)
ground bearing capacity
VIS-NIR
LWIR
SWIR
multispectral
soil moisture
optical filters
penetrometer
soil compaction
VIS-NIR, SWIR and LWIR Imagery for Estimation of Ground Bearing Capacity
info:eu-repo/semantics/article
oai:zenodo.org:154582
2020-01-20T15:34:17Z
user-fp7postgrantoapilotoutputs
user-eu
Cheronet, Olivia
Finarelli, John A.
Pinhasi, Ron
2016-09-13
<p>The Neolithic transition brought about fundamental social, dietary and behavioural changes in human populations, which, in turn, impacted skeletal morphology. Crania are shaped through diverse genetic, ontogenetic and environmental factors, reflecting various elements of an individual’s life. To determine the transition’s effect on cranial morphology, we investigated its potential impact on the face and vault, two elements potentially responding to different influences. Three datasets from geographically distant regions (Ukraine, Iberia, and the Levant plus Anatolia) were analysed. Craniometric measurements were used to compare the morphology of pre-transition populations with that of agricultural populations. The Neolithic transition corresponds to a statistically significant increase only in cranial breadth of the Ukrainian vaults, while facial morphology shows no consistent transformations, despite expected changes related to the modification of masticatory behaviour. The broadening of Ukrainian vaults may be attributable to dietary and/or social changes. However, the lack of change observed in the other geographical regions and the lack of consistent change in facial morphology are surprising. Although the transition from foraging to farming is a process that took place repeatedly across the globe, different characteristics of transitions seem responsible for idiosyncratic responses in cranial morphology.</p>
EUR 1,165 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/srep33316
oai:zenodo.org:154582
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Scientific Reports, 6, 33316, (2016-09-13)
biological anthropology
evolution
Morphological change in cranial shape following the transition to agriculture across western Eurasia
info:eu-repo/semantics/article
oai:zenodo.org:46966
2020-01-20T15:02:37Z
user-fp7postgrantoapilotoutputs
user-eu
Rivet, Sylvain
Maria, Michael
Bradu, Adrian
Feuchter, Thomas
Leick, Lasse
Podoleanu, Adrian
2016-02-04
<p>A general theoretical model is developed to improve the novel Spectral Domain Interferometry method denoted as Master/Slave (MS) Interferometry. In this model, two functions, <em>g</em> and <em>h</em> are introduced to describe the modulation chirp of the channeled spectrum signal due to nonlinearities in the decoding process from wavenumber to time and due to dispersion in the interferometer. The utilization of these two functions brings two major improvements to previous implementations of the MS method. A first improvement consists in reducing the number of channeled spectra necessary to be collected at Master stage. In previous MSI implementation, the number of channeled spectra at the Master stage equated the number of depths where information was selected from at the Slave stage. The paper demonstrates that two experimental channeled spectra only acquired at Master stage suffice to produce A-scans from any number of resolved depths at the Slave stage. A second improvement is the utilization of complex signal processing. Previous MSI implementations discarded the phase. Complex processing of the electrical signal determined by the channeled spectrum allows phase processing that opens several novel avenues. A first consequence of such signal processing is reduction in the random component of the phase without affecting the axial resolution. In previous MSI implementations, phase instabilities were reduced by an average over the wavenumber that led to reduction in the axial resolution.</p>
$2,664 APC fee partially funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1364/OE.24.002885
oai:zenodo.org:46966
https://pubmed.ncbi.nlm.nih.gov/26906857
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Other (Open)
Optics Express, 24(3), 2885-2904, (2016-02-04)
(110.4500) Optical coherence tomography
(120.3890) Medical optics instrumentation
(110.4190) Multiple imaging
(170.4460) Ophthalmic optics and devices
Complex master slave interferometry
info:eu-repo/semantics/article
oai:zenodo.org:154581
2020-01-20T15:28:56Z
user-fp7postgrantoapilotoutputs
user-eu
Galland, Manon
Van Gerven, Denis P.
Von Cramon-Taubadel, Noreen
Pinhasi, Ron
2016-08-09
<p>The transition to agriculture was a key event in human history. The extent to which this transition is associated with biological changes in different world regions remains debated. Cultural and osteological records in Lower Nubia throughout the Holocene have been interpreted as a result of <em>in situ</em> differentiation or alternatively as migratory events and possible admixture with surrounding populations. Here we investigated the patterns of craniofacial and mandibular variation from Mesolithic hunting-gathering to late farming, a period spanning 11,000 years. We analyzed 102 adult specimens spanning five cultural horizons: Mesolithic, A-group, C-group, Pharaonic and Meroitic, by means of 3D geometric morphometric methods, in order to assess shape variation and diachronic patterns at the transition to farming and in subsequent periods. Our results highlight a strong morphometric distinction between Mesolithic hunter-gatherers and farmers as well as differences between transitional and intensive farmers in mandibular variation which is consistent with differential impact of selective pressures on different regions of the skull. This study corroborates a major biological change during the transition from hunting to farming, supporting the masticatory-functional hypothesis for the mandible and suggesting population continuity among farming populations throughout the Holocene based on the overall shape of the cranium.</p>
EUR 1,165 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/srep31040
oai:zenodo.org:154581
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Scientific Reports, 6, 31040, (2016-08-09)
anthropology
archaeology
11,000 years of craniofacial and mandibular variation in Lower Nubia
info:eu-repo/semantics/article
oai:zenodo.org:20176
2020-01-20T14:32:29Z
user-fp7postgrantoapilotoutputs
user-eu
Božić, Dragana
Papaefthimiou, Dimitra
Brückner, Kathleen
De Vos, Ric C. H.
Tsoleridis, Constantinos A.
Katsarou, Dimitra
Papanikolaou, Antigoni
Pateraki, Irini
Chatzopoulou, Fani M.
Dimitriadou, Eleni
Kostas, Stefanos
Manzano, David
Scheler, Ulschan
Ferrer, Albert
Tissier, Alain
Makris, Antonios M.
Kampranis, Sotirios C.
Kanellis, Angelos K.
2015-05-28
<p>Carnosic acid (CA) is a phenolic diterpene with anti-tumour, anti-diabetic, antibacterial and neuroprotective properties that is produced by a number of species from several genera of the<em>Lamiaceae</em> family, including <em>Salvia fruticosa</em> (Cretan sage) and <em>Rosmarinus officinalis</em>(Rosemary). To elucidate CA biosynthesis, glandular trichome transcriptome data of <em>S</em>. <em>fruticosa</em>were mined for terpene synthase genes. Two putative diterpene synthase genes, namely<em>SfCPS </em>and <em>SfKSL</em>, showing similarities to copalyl diphosphate synthase and kaurene synthase-like genes, respectively, were isolated and functionally characterized. Recombinant expression in <em>Escherichia coli</em> followed by <em>in vitro</em> enzyme activity assays confirmed that SfCPS is a copalyl diphosphate synthase. Coupling of SfCPS with SfKSL, both <em>in vitro</em> and in yeast, resulted in the synthesis miltiradiene, as confirmed by 1D and 2D NMR analyses (1H, 13C, DEPT, COSY H-H, HMQC and HMBC). Coupled transient <em>in vivo</em> assays of <em>SfCPS</em> and <em>SfKSL</em> in <em>Nicotiana benthamiana</em> further confirmed production of miltiradiene <em>in planta</em>. To elucidate the subsequent biosynthetic step, RNA-Seq data of <em>S</em>. <em>fruticosa</em> and <em>R</em>. <em>officinalis</em> were searched for cytochrome P450 (CYP) encoding genes potentially involved in the synthesis of the first phenolic compound in the CA pathway, ferruginol. Three candidate genes were selected, <em>SfFS</em>, <em>RoFS1</em> and <em>RoFS2</em>. Using yeast and <em>N</em>. <em>benthamiana</em> expression systems, all three where confirmed to be coding for ferruginol synthases, thus revealing the enzymatic activities responsible for the first three steps leading to CA in two <em>Lamiaceae</em> genera.</p>
USD 1350 APC fee covered by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1371/journal.pone.0124106
oai:zenodo.org:20176
Zenodo
https://pubmed.ncbi.nlm.nih.gov/26020634
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Trichomes
Leaves
Gas chromatography-mass spectrometry
Sequence motif analysis
Yeast
Hexanes
Biosynthesis
Polymerase chain reaction
Towards elucidating carnosic acid biosynthesis in Lamiaceae: functional characterization of the three first steps of the pathway in Salvia fruticosa and Rosmarinus officinalis
info:eu-repo/semantics/article
oai:zenodo.org:163955
2020-01-20T17:30:05Z
user-fp7postgrantoapilotoutputs
user-eu
Jan van Lieshout
Elke Huntink
Jan Koetsenruijter
Michel Wensing
2016-08-11
<p>Counselling on health-related lifestyles is key to the prevention and management of chronic diseases. After comprehensive study of determinants of its delivery in general practice and strategies to improve, we composed a tailored improvement program, which included communication skills training, online patient information, and a clinical protocol for managing depressive symptoms. Our aim was to assess the effectiveness of this program on professional performance and outcomes in cardiovascular patients. A two-arm cluster randomized trial in 34 general practices involving 34 nurses was conducted. The primary outcome was an aggregated score of a positive score on lifestyle counselling delivered and an appropriate action on depressive symptoms. Secondary outcomes included the various elements of the primary outcome, vascular risk factors (extracted from patient records), and patient-reported lifestyle behaviors. Data were collected from medical records and a written survey among included patients. A sample of 1782 patients with recorded cardiovascular disease or high cardiovascular risk was available at follow-up at 6 months. No impact on the primary outcome was found; lifestyle counselling was recorded in a minority of patients (11.4 % in the intervention group and 10.3 % in the control group). An effect was found on a secondary outcome: patients’ physical activity level increased (B 0.18; 95 % CI 0.02–0.35) on a seven-point scale. The tailored improvement program showed no effect on the primary outcome. This challenges the methodology of tailoring. More involvement of the targeted health care professionals might offer ways to develop more effective implementation programs. Physical activity might be the lifestyle issue that can be more easily changed than smoking or dietary habits.</p>
EUR 1538.50 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1186/s13012-016-0460-0
oai:zenodo.org:163955
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Implementation
Risk factors
Tailored interventions
Cardiovascular disease
Primary care
Lifestyle
Counselling
Randomized controlled trial
Cluster randomization
Tailored implementation of cardiovascular risk management in general practice: a cluster randomized trial
info:eu-repo/semantics/article
oai:zenodo.org:1063922
2020-01-20T16:15:13Z
user-fp7postgrantoapilotoutputs
user-eu
Eric Armengaud (Ed.)
Riccardo Groppo (Ed.)
Sven Rzepka (Ed.)
2017-11-21
<p>Electro-mobility is considered as a key technology to achieve green mobility and fulfil tomorrow’s emission standards. However, different challenges still need to be faced to achieve comparable performances to conventional vehicles and finally obtain market acceptance. Two of these challenges are vehicle range and production costs. In that context, the aim of the INCOBAT project (October 2013 – December 2016) was to provide innovative and cost efficient battery management systems for next generation HV-batteries. INCOBAT presents a platform concept that achieves cost reduction, reduced complexity, increased reliability and flexibility while at the same time reaching higher energy efficiency. Advantages of this approach include:</p>
<ul>
<li>Tight control of the cell function leading to a significant increase of the driving range of the FEV;</li>
<li>Radical cost reduction of the battery management system with respect to current solutions;</li>
<li>Development of modular concepts for system architecture and partitioning, safety, security, reliability as well as verification and validation, thus enabling efficient integration into different vehicle platforms.</li>
</ul>
<p> </p>
<p>The INCOBAT project focused on the following twelve technical innovations grouped into four innovation groups, which are summarized in this book:</p>
<ul>
<li>Customer needs and integration aspects</li>
<li>Transversal innovation</li>
<li>Technology innovation</li>
</ul>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519626
oai:zenodo.org:1063922
eng
River Publishers
https://d-nb.info/gnd/978-87-93519-63-3 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Electric vehicle
High voltage battery
Battery management system
Multi-core computing platform
Functional safety
Systems engineering
Electrochemical impedance spectroscopy
Thermomechanical robustness analysis
INCOBAT: Innovative Cost Efficient Management System for Next Generation High Voltage Batteries
info:eu-repo/semantics/book
oai:zenodo.org:23528
2020-01-20T14:15:28Z
user-fp7postgrantoapilotoutputs
user-eu
Fernandez-López, Raul
Ruiz, Raul
De la Cruz, Fernando
Moncalián, Gabriel
2015-07-01
<p>Whole cell biosensors (WCBs) have multiple applications for environmental monitoring, detecting a wide range of pollutants. WCBs depend critically on the sensitivity and specificity of the transcription factor (TF) used to detect the analyte. We describe the mechanism of regulation and the structural and biochemical properties of TF families that are used, or could be used, for the development of environmental WCBs. Focusing on the chemical nature of the analyte, we review TFs that respond to aromatic compounds (XylS-AraC, XylR-NtrC, and LysR), metal ions (MerR, ArsR, DtxR, Fur, and NikR) or antibiotics (TetR and MarR). Analyzing the structural domains involved in DNA recognition, we highlight the similitudes in the DNA binding domains (DBDs) of these TF families. Opposite to DBDs, the wide range of analytes detected by TFs results in a diversity of structures at the effector binding domain. The modular architecture of TFs opens the possibility of engineering TFs with hybrid DNA and effector specificities. Yet, the lack of a crisp correlation between structural domains and specific functions makes this a challenging task.</p>
USD 1425 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fmicb.2015.00648
oai:zenodo.org:23528
https://pubmed.ncbi.nlm.nih.gov/26191047
https://www.ncbi.nlm.nih.gov/pmc/PMC4486848
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Frontiers in Microbiology, (2015-07-01)
biosensors
transcription factor
effector
aromatic compounds
metal
analyte
Transcription factor-based biosensors enlightened by the analyte
info:eu-repo/semantics/article
oai:zenodo.org:1003194
2020-01-20T13:43:28Z
user-fp7postgrantoapilotoutputs
user-eu
J. Leonie Cazemier
Francisco Clascá
Paul H. E. Tiesinga
2016-11-09
<p>Brain networks, localized or brain-wide, exist only at the cellular level, i.e., between specific pre- and post-synaptic neurons, which are connected through functionally diverse synapses located at specific points of their cell membranes. “Connectomics” is the emerging subfield of neuroanatomy explicitly aimed at elucidating the wiring of brain networks with cellular resolution and a quantified accuracy. Such data are indispensable for realistic modeling of brain circuitry and function. A connectomic analysis, therefore, needs to identify and measure the soma, dendrites, axonal path, and branching patterns together with the synapses and gap junctions of the neurons involved in any given brain circuit or network. However, because of the submicron caliber, 3D complexity, and high packing density of most such structures, as well as the fact that axons frequently extend over long distances to make synapses in remote brain regions, creating connectomic maps is technically challenging and requires multi-scale approaches, Such approaches involve the combination of the most sensitive cell labeling and analysis methods available, as well as the development of new ones able to resolve individual cells and synapses with increasing high-throughput. In this review, we provide an overview of recently introduced high-resolution methods, which researchers wanting to enter the field of connectomics may consider. It includes several molecular labeling tools, some of which specifically label synapses, and covers a number of novel imaging tools such as brain clearing protocols and microscopy approaches. Apart from describing the tools, we also provide an assessment of their qualities. The criteria we use assess the qualities that tools need in order to contribute to deciphering the key levels of circuit organization. We conclude with a brief future outlook for neuroanatomic research, computational methods, and network modeling, where we also point out several outstanding issues like structure–function relations and the complexity of neural models.</p>
USD 1245.00 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fnana.2016.00110
oai:zenodo.org:1003194
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
connectome mapping, brain clearing, neuronal labeling, whole-brain imaging, mouse connectome, Bayesian modeling, connectome models, Peter's rule
Connectomic Analysis of Brain Networks: Novel Techniques and Future Directions
info:eu-repo/semantics/article
oai:zenodo.org:44594
2020-01-20T17:21:34Z
user-fp7postgrantoapilotoutputs
user-eu
Pieszko, Marta
Weir, William
Goodhead, Ian
Kinnaird, Jane
Shiels, Brian
2015-08-14
<p>The ability of vector-borne Apicomplexan parasites (<em>Babesia</em>, <em>Plasmodium</em> and <em>Theileria</em>) to change from one life-cycle stage to the next is critical for establishment of infection and transmission to new hosts. Stage differentiation steps of both <em>Plasmodium</em> and <em>Theileria</em> are known to involve stochastic transition through an intermediate form to a point that commits the cell to generate the next stage in the life-cycle. In this study we have identified genes encoding ApiAP2 DNA binding proteins in <em>Theileria annulata</em> that are differentially expressed during differentiation from the macroschizont stage, through merozoite production (merogony) to the piroplasm stage. The results provide evidence that the ApiAp2 factor in <em>Theileria</em> that possesses the orthologue of the <em>Plasmodium</em> AP2-G domain may also operate to regulate gametocytogenesis, and that progression to merogony is promoted by the ability of a merozoite DNA binding protein to preferentially up-regulate its own production. In addition, identification of multiple ApiAP2 DNA binding domains that bind related motifs within and across vector-borne Apicomplexan genera lead to the proposal that the mechanisms that promote the transition from asexual to sexual replication will show a degree of conservation.</p>
USD 2250 APC fee co-funded by the EC FP7 Post-Grant Open Access Pilot (together with the University of Glasgow)
https://doi.org/10.1371/journal.pntd.0003933
oai:zenodo.org:44594
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata
info:eu-repo/semantics/article
oai:zenodo.org:57907
2020-01-20T15:01:24Z
user-fp7postgrantoapilotoutputs
Roepman, Ronald
Boldt, Karsten
van Reeuwijk, Jeroen
Lu, Qianhao
2016-05-13
<p>Cellular organelles provide opportunities to relate biological mechanisms to disease. Here we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood organelles, where defects cause genetic diseases. Two hundred and seventeen tagged human ciliary proteins create a final landscape of 1,319 proteins, 4,905 interactions and 52 complexes. Reverse tagging, repetition of purifications and statistical analyses, produce a high-resolution network that reveals organellespecific interactions and complexes not apparent in larger studies, and links vesicle transport, the cytoskeleton, signalling and ubiquitination to ciliary signalling and proteostasis. We observe sub-complexes in exocyst and intraflagellar transport complexes, which we validate biochemically, and by probing structurally predicted, disruptive, genetic variants from ciliary disease patients. The landscape suggests other genetic diseases could be ciliary including 3M syndrome. We show that 3M genes are involved in ciliogenesis, and that patient fibroblasts lack cilia. Overall, this organelle-specific targeting strategy shows considerable promise for Systems Medicine.</p>
USD 4400 APC fee partially funded (2000 euros) by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/ncomms11491
oai:zenodo.org:57907
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Biological sciences; Bioinformatics; Cell biology
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
info:eu-repo/semantics/article
oai:zenodo.org:48576
2020-01-20T15:03:49Z
user-fp7postgrantoapilotoutputs
XIURONG JIAO
KIRSTEN KØRUP
MATHIAS NEUMANN ANDERSEN
ERIK J . SACKS
XIN-GUANG ZHU
POUL ERIK LÆRKE
UFFE JØRGENSEN
2016-02-29
<p>Miscanthus, a perennial grass with C<sub>4</sub> photosynthesis, is regarded as a promising energy crop due to its high biomass productivity. Compared with other C<sub>4</sub> species, most miscanthus genotypes have high cold tolerances at 14ºC. However, in temperate climates, temperatures below 14ºC are common and our aim was to elucidate cold tolerances of different miscanthus genotypes and compare with a C<sub>3</sub> perennial grass - festulolium. Eleven genotypes of <em>M. sacchariflorus, M. sinensis, M. tinctorius</em>, <em>M</em>. x <em>giganteus</em> as well as festulolium were grown under warm (24/20ºC, day/night) and three under cold (14/10ºC, 10/8ºC and 6/4ºC) conditions in a controlled environment. Measurements of photosynthetic light response curves, operating quantum yield of photosystem II (ΦPSII), net photosynthetic rate at a PAR of 1000 lmol m<sup>-2</sup> s<sup>-1</sup> (A<sub>1000</sub>) and dark-adapted chlorophyll fluorescence (Fv/Fm) were made at each temperature. In addition, temperature response curves were measured after the plants had been grown at 6/4ºC. The results showed that two tetraploid <em>M. sacchariflorus </em>and the standard triploid <em>M</em>. x <em>giganteus</em> cv. Hornum retained a significantly higher photosynthetic capacity than other miscanthus genotypes at each temperature level and still maintained photosynthesis after growing for a longer period at 6/4ºC. Only two of five measured miscanthus genotypes increased photosynthesis immediately after the temperature was raised again. The photosynthetic capacity of festulolium was significantly higher at 10/8ºC and 6/4ºC than of miscanthus genotypes. This indicates that festulolium may be more productive than the currently investigated miscanthus genotypes in cool, maritime climates. Within miscanthus, only one <em>M. sacchariflorus </em>genotype exhibited the same photosynthetic capacity as Hornum at both cold conditions and when the temperature was raised again. Therefore, this genotype could be useful for breeding new varieties with an improved cold tolerance vis-a-vis Hornum, and be valuable in broadening the genetic diversity of miscanthus for more widespread cultivation in temperate climates.</p>
https://doi.org/10.1111/gcbb.12342
oai:zenodo.org:48576
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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C3 photosynthesis, C4 photosynthesis, chlorophyll fluorescence, cold tolerance, genotype difference, light response
Can miscanthus C4 photosynthesis compete with festulolium C3 photosynthesis in a temperate climate?
info:eu-repo/semantics/article
oai:zenodo.org:1168372
2020-01-20T16:20:58Z
user-fp7postgrantoapilotoutputs
Pajic, Srbislav S.
Antic, Svetlana
Vukicevic, Arso M.
Djordjevic, Nenad
Jovicic. Gordana
Savic, Zivorad
Saveljic, Igor
Janovic, Aleksa
Pesic, Zoran
Djuric, Marija
Filipovic, Nenad
2017-07-11
<p>Anatomy of frontal sinuses varies individually, from differences in volume and shape to<br>
a rare case when the sinuses are absent. However, there are scarce data related to<br>
influence of these variations on impact generated fracture pattern. Therefore, the aim of<br>
this study was to analyse the influence of frontal sinus volume on the stress distribution<br>
and fracture pattern in the frontal region. The study included four representative Finite<br>
Element models of the skull. Reference model was built on the basis of computed<br>
tomography scans of a human head with normally developed frontal sinuses. By<br>
modifying the reference model, three additional models were generated: a model without<br>
sinuses, with hypoplasic, and with hyperplasic sinuses. A 7.7 kN force was applied<br>
perpendicularly to the forehead of each model, in order to simulate a frontal impact. The<br>
results demonstrated that the distribution of impact stress in frontal region depends on<br>
the frontal sinus volume. The anterior sinus wall showed the highest fragility in case with<br>
hyperplasic sinuses, whereas posterior wall/inner plate showed more fragility in cases<br>
with hypoplasic and undeveloped sinuses.Well-developed frontal sinusesmight, through<br>
absorption of the impact energy by anterior wall, protect the posterior wall and intracranial<br>
contents.</p>
https://doi.org/10.3389/fphys.2017.00493
oai:zenodo.org:1168372
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Frontiers in Physiology, 8, Article 493, (2017-07-11)
frontal sinus
fracture
frontal bone
finite element analysis
modeling
Trauma of the Frontal Region Is Influenced by the Volume of Frontal Sinuses. A Finite Element Study
info:eu-repo/semantics/article
oai:zenodo.org:887608
2020-01-20T17:28:43Z
user-fp7postgrantoapilotoutputs
user-eu
Andrea Bondavalli (Ed.)
Francesco Brancati (Ed.)
2017-09-08
<p>In recent years, a considerable amount of effort has been devoted, both in industry and academia, to the development, validation and verification of critical systems, i.e. those systems whose malfunctions or failures reach a critical level both in terms of risks to human life as well as having a large economic impact.</p>
<p><em>Certifications of Critical Systems – The CECRIS Experience</em> documents the main insights on Cost Effective Verification and Validation processes that were gained during work in the European Research Project CECRIS (Certification of Critical Systems). The objective of the research was to tackle the challenges of certification by focusing on those aspects that turn out to be more difficult/important for current and future critical systems industry: the effective use of methodologies, processes and tools.</p>
<p>Starting from both the scientific and industrial state of the art methodologies for system development and the impact of their usage on the verification and validation and certification of critical systems, the project aimed at developing strategies and techniques supported by automatic or semi-automatic tools and methods for these activities, setting guidelines to support engineers during the planning of the verification and validation phases.</p>
<p>Topics covered include: Safety Assessment, Reliability Analysis, Critical Systems and Applications, Functional Safety, Dependability Validation, Dependable Software Systems, Embedded Systems, System Certification.</p>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519558
oai:zenodo.org:887608
River Publishers
isbn:978-87-93519-56-5
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Safety Assessment
Reliability Analysis
Critical Systems and Applications
Functional Safety
Dependability Validation
Dependable Software Systems
Embedded Systems
System Certification
Certifications of Critical Systems – The CECRIS Experience
info:eu-repo/semantics/book
oai:zenodo.org:154486
2020-01-20T15:46:49Z
user-fp7postgrantoapilotoutputs
user-eu
Rickard, Geoff
Iskilibli, Ozan
Williams, Paul
Beigh, Reece
Del Regno, Renato
Baumheinrich, Thorsten
Solomko, Valentyn
Stoica, Lucian (ed.)
Riches, Steve (ed.)
Johnston, Colin (ed.)
2016-09-20
<p>There is a growing desire to install electronic power and control systems in high temperature harsh environments to improve the accuracy of critical measurements, reduce the amount of cabling and to eliminate cooling systems. Typical target applications include electronics for energy exploration, power generation and control systems. <br>
<br>
Technical topics presented in this book include:</p>
<ul>
<li>High temperature electronics market</li>
<li>High temperature devices, materials and assembly processes</li>
<li>Design, manufacture and testing of multi-sensor data acquisition system for aero-engine control</li>
<li>Future applications for high temperature electronics</li>
</ul>
<p><em>High Temperature Electronics</em> Design for Aero Engine Controls and Health Monitoring contains details of state of the art design and manufacture of electronics targeted towards a high temperature aero-engine application.</p>
€6,000 BPC fee covered by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793379244
oai:zenodo.org:154486
River Publishers
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
electronic power and control systems
electronics
aviation
high temperature electronics
multi-sensor data acquisition systems
aero-engine control
High Temperature Electronics Design for Aero Engine Controls and Health Monitoring
info:eu-repo/semantics/book
oai:zenodo.org:826523
2020-01-20T17:03:34Z
user-fp7postgrantoapilotoutputs
user-eu
Joan Cabestany (Ed.)
Àngels Bayés (Ed.)
2017-07-13
<p>Parkinson’s Disease (PD) is a neurodegenerative disorder that manifests with motor and non-motor symptoms. PD treatment is symptomatic and tries to alleviate the associated symptoms through an adjustment of the medication. As the disease is evolving and this evolution is patient specific, it could be very difficult to properly manage the disease.</p>
<p>The current available technology (electronics, communication, computing, etc.), correctly combined with wearables, can be of great use for obtaining and processing useful information for both clinicians and patients allowing them to become actively involved in their condition.</p>
<p><em>Parkinson’s Disease Management through ICT: The REMPARK Approach</em> presents the work done, main results and conclusions of the REMPARK project (2011 – 2015) funded by the European Union under contract FP7-ICT-2011-7-287677. REMPARK system was proposed and developed as a real Personal Health Device for the Remote and Autonomous Management of Parkinson’s Disease, composed of different levels of interaction with the patient, clinician and carers, and integrating a set of interconnected sub-systems: sensor, auditory cueing, Smartphone and server. The sensor subsystem, using embedded algorithmics, is able to detect the motor symptoms associated with PD in real time. This information, sent through the Smartphone to the REMPARK server, is used for an efficient management of the disease.</p>
<p>Implementation of REMPARK will increase the independence and Quality of Life of patients; and improve their disease management, treatment and rehabilitation.</p>
<p> </p>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519459
oai:zenodo.org:826523
River Publishers
https://d-nb.info/gnd/978-87-93519-46-6 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Parkinson's disease
disease management
wearing off fluctuations
dyskinesia's
Freezing of gait
ON/OFF states detection
automatic detection of motor symptoms
wearable sensors
auditory cueing system
Parkinson's Disease Management through ICT: The REMPARK Approach
info:eu-repo/semantics/book
oai:zenodo.org:1298587
2019-12-12T12:10:28Z
user-fp7postgrantoapilotoutputs
user-openaire
user-eu
Gwen Franck
2018-04-30
<p>*description edited on August 29 2019*</p>
<p>Versions in reverse order of publication.</p>
<p><strong>D 5.6: OpenAIRE WP5: Final periodic report on APC uptake and metrics</strong></p>
<p><strong>D 5.5: ROADMAP FOR A SUSTAINABLE AND COMPETITIVE MARKET FOR OPEN ACCESS PUBLISHING</strong></p>
<p><strong>D 5.4: Second periodic report on APC uptake and metrics: </strong>the deliverable based on 20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</p>
<p><strong>20180618_OpenAIRE2020_FP7PostGrantPilot_data.xlsx:</strong> update of the last dataset - status of 65 publications in progress changed to 'paid'. This has no significant influence on the statistical analysis already made, as the estimated data was already processed. </p>
<p><strong>20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</strong> : These datasets contain all datasets related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot from its start in May 1st 2015 until February 28th 2018. The final report of the Pilot will be based on this dataset. </p>
<p><strong><a href="https://zenodo.org/api/files/31b3b7e0-98f6-42a0-a82f-543898dfb6bc/20170831_DatasetD5.4.xlsx?versionId=e1d01078-50fa-4997-b8b9-6efa86180f37">20170831_DatasetD5.4.xlsx</a></strong>: This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).</p>
<p>A final version will be added to this record once all remaining accounting is wrapped up (July 2018). However, we are confident that the numbers presented here show trends and averages adequately, even if the absolute numbers will still change slightly. </p>
<p>The Pilot website can be found at : https://postgrantoapilot.openaire.eu</p>
<p>To be eligible, a publication needed to comply with the following conditions: </p>
<ul>
<li>Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication P</li>
<li>ublished in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole </li>
<li>Maximum 3 publications per project</li>
<li>The funding cap is € 2000 for articles and € 6000 for monographs.</li>
</ul>
<p>Some author fees exceed this cap slightly due to currency conversion. Any other anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. </p>
<p><br>
All materials available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this data. Feel free to ping us when you make use of it. </p>
<p>Author: Gwen Franck gwenfranckgcv@gmail.com</p>
<p>OpenAIRE on Twitter @openaire_eu</p>
<p>info@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.1298587
oai:zenodo.org:1298587
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
MS 72: OpenAIRE WP5: Final periodic report on APC uptake and metrics
info:eu-repo/semantics/other
oai:zenodo.org:1003208
2020-01-20T14:29:37Z
user-fp7postgrantoapilotoutputs
user-eu
Silvan Quax
Ole Jensen
Paul Tiesinga
2017-05-04
<p>Selective routing of information between cortical areas is required in order to combine different sources of information according to cognitive demand. Recent experiments have suggested that alpha band activity originating from the pulvinar coordinates this inter-areal cortical communication. Using a computer model we investigated whether top-down induced shifts in the relative alpha phase between two cortical areas could modulate cortical communication, quantified in terms of changes in gamma band coherence between them. The network model was comprised of two uni-directionally connected neuronal populations of spiking neurons, each representing a cortical area. We find that the phase difference of the alpha oscillations modulating the two neuronal populations strongly affected the interregional gamma-band neuronal coherence. We confirmed that a higher gamma band coherence also resulted in more efficient transmission of spiking information between cortical areas, thereby confirming the value of gamma coherence as a proxy for cortical information transmission. In a model where both neuronal populations were connected bi-directionally, the relative alpha phase determined the directionality of communication between the populations. Our results show the feasibility of a physiological realistic mechanism for routing information in the brain based on coupled oscillations. Our model results in a set of testable predictions regarding phase shifts in alpha oscillations under different task demands requiring experimental quantification of neuronal oscillations in different regions in e.g. attention paradigms.</p>
USD 2250.00 APC fee partially funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1371/journal.pcbi.1005519
oai:zenodo.org:1003208
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Top-down control of cortical gamma-band communication via pulvinar induced phase shifts in the alpha rhythm
info:eu-repo/semantics/article
oai:zenodo.org:1050166
2020-01-20T15:57:43Z
user-fp7postgrantoapilotoutputs
user-eu
Pyrina, Maria
Wagner, Sebastian
Zorita, Eduardo
2017-10-13
<p>Two statistical methods are tested to reconstruct the interannual variations in past sea surface temperatures (SSTs) of the North Atlantic (NA) Ocean over the past millennium based on annually resolved and absolutely dated marine proxy records of the bivalve mollusk <em>Arctica islandica</em>. The methods are tested in a pseudo-proxy experiment (PPE) setup using state-of-the-art climate models (CMIP5 Earth system models) and reanalysis data from the COBE2 SST data set. The methods were applied in the virtual reality provided by global climate simulations and reanalysis data to reconstruct the past NA SSTs using pseudo-proxy records that mimic the statistical characteristics and network of <em>Arctica islandica</em>. The multivariate linear regression methods evaluated here are principal component regression and canonical correlation analysis. Differences in the skill of the climate field reconstruction (CFR) are assessed according to different calibration periods and different proxy locations within the NA basin. The choice of the climate model used as a surrogate reality in the PPE has a more profound effect on the CFR skill than the calibration period and the statistical reconstruction method. The differences between the two methods are clearer for the MPI-ESM model due to its higher spatial resolution in the NA basin. The pseudo-proxy results of the CCSM4 model are closer to the pseudo-proxy results based on the reanalysis data set COBE2. Conducting PPEs using noise-contaminated pseudo-proxies instead of noise-free pseudo-proxies is important for the evaluation of the methods, as more spatial differences in the reconstruction skill are revealed. Both methods are appropriate for the reconstruction of the temporal evolution of the NA SSTs, even though they lead to a great loss of variance away from the proxy sites. Under reasonable assumptions about the characteristics of the non-climate noise in the proxy records, our results show that the marine network of <em>Arctica islandica</em> can be used to skillfully reconstruct the spatial patterns of SSTs at the eastern NA basin.</p>
https://doi.org/10.5194/cp-13-1339-2017
oai:zenodo.org:1050166
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Climate of the past, 13(10), 1339-1354, (2017-10-13)
North Atlantic Ocean
Sea surface
Temperature reconstruction
Arctica islandica
Bivalvia
Climate modelling
Pseudo-proxy experiment
Pseudo-proxy evaluation of climate field reconstruction methods of North Atlantic climate based on an annually resolved marine proxy network
info:eu-repo/semantics/article
oai:zenodo.org:1155582
2020-01-20T14:55:50Z
user-fp7postgrantoapilotoutputs
user-biosense_institute
Jankovic Nikolina
Cselyuszka Norbert
2018-01-19
<p>We present a Fano metal-insulator-metal (MIM) structure based on an isosceles triangular cavity resonator for refractive index sensing applications. Due to the specific feeding scheme and asymmetry introduced in the triangular cavity, the resonator exhibits four sharp Fano-like resonances. The behavior of the structure is analyzed in detail and its sensing capabilities demonstrated through the responses for various refractive indices. The results show that the sensor has very good sensitivity and maximal figure of merit (FOM) value of 3.2 x 10<sup>5</sup>. In comparison to other similar sensors, the proposed one has comparable sensitivity and significantly higher FOM,<br>
which clearly demonstrates its high sensing potential.</p>
https://doi.org/10.3390/s18010287
oai:zenodo.org:1155582
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/biosense_institute
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
1, (2018-01-19)
Fano resonance
Metal-insulator-metal
Plasmonic sensor
Triangular cavity
Multiple Fano-Like MIM Plasmonic Structure Based on Triangular Resonator for Refractive Index Sensing
info:eu-repo/semantics/article
oai:zenodo.org:48621
2020-01-20T14:42:40Z
user-fp7postgrantoapilotoutputs
user-eu
Kaminski, T.
Kauker, F.
Eicken, H.
Karcher, M.
2015-08-27
<p>We present a quantitative network design (QND) study of the Arctic sea ice–ocean system using a software tool that can evaluate hypothetical observational networks in a variational data assimilation system. For a demonstration, we evaluate two idealised flight transects derived from NASA's Operation IceBridge airborne ice surveys in terms of their potential to improve 10-day to 5-month sea ice forecasts. As target regions for the forecasts we select the Chukchi Sea, an area particularly relevant for maritime traffic and offshore resource exploration, as well as two areas related to the Barnett ice severity index (BSI), a standard measure of shipping conditions along the Alaskan coast that is routinely issued by ice services. Our analysis quantifies the benefits of sampling upstream of the target area and of reducing the sampling uncertainty. We demonstrate how observations of sea ice and snow thickness can constrain ice and snow variables in a target region and quantify the complementarity of combining two flight transects. We further quantify the benefit of improved atmospheric forecasts and a well-calibrated model.</p>
€850 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.5194/tc-9-1721-2015
oai:zenodo.org:48621
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
The Cryosphere, 9, 1721-1733, (2015-08-27)
quantitative network design
data assimilation
sea ice
Arctic
sampling strategies
Exploring the utility of quantitative network design in evaluating Arctic sea ice thickness sampling strategies
info:eu-repo/semantics/article
oai:zenodo.org:49990
2020-01-20T13:32:28Z
user-fp7postgrantoapilotoutputs
user-eu
Donnarumma, Francesco
Maisto, Domenico
Pezzulo, Giovanni
2016-04-13
<p>How do humans and other animals face novel problems for which predefined solutions are not available? Human problem solving links to flexible reasoning and inference rather than to slow trial-and-error learning. It has received considerable attention since the early days of cognitive science, giving rise to well known cognitive architectures such as SOAR and ACT-R, but its computational and brain mechanisms remain incompletely known. Furthermore, it is still unclear whether problem solving is a “specialized” domain or module of cognition, in the sense that it requires computations that are fundamentally different from those supporting perception and action systems. Here we advance a novel view of human problem solving as <em>probabilistic inference with subgoaling</em>. In this perspective, key insights from cognitive architectures are retained such as the importance of using subgoals to split problems into subproblems. However, here the underlying computations use probabilistic inference methods analogous to those that are increasingly popular in the study of perception and action systems. To test our model we focus on the widely used Tower of Hanoi (ToH) task, and show that our proposed method can reproduce characteristic idiosyncrasies of human problem solvers: their sensitivity to the “community structure” of the ToH and their difficulties in executing so-called “counterintuitive” movements. Our analysis reveals that subgoals have two key roles in probabilistic inference and problem solving. First, prior beliefs on (likely) useful subgoals carve the problem space and define an implicit metric for the problem at hand—a metric to which humans are sensitive. Second, subgoals are used as <em>waypoints</em> in the probabilistic problem solving inference and permit to find effective solutions that, when unavailable, lead to problem solving deficits. Our study thus suggests that a probabilistic inference scheme enhanced with subgoals provides a comprehensive framework to study problem solving and its deficits.</p>
USD 2,000 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.-- The simulation source code can be downloaded from https://sites.google.com/site/francescodonnarumma/hanoi_subgoals.tar?attredirects=0
https://doi.org/10.1371/journal.pcbi.1004864
oai:zenodo.org:49990
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
PLoS Computational Biology, 12(4), e1004864, (2016-04-13)
Problem solving
Probability distribution
Cognition
Sensory perception
Behavior
Decision making
Algorithms
Learning
Problem Solving as Probabilistic Inference with Subgoaling: Explaining Human Successes and Pitfalls in the Tower of Hanoi
info:eu-repo/semantics/article
oai:zenodo.org:221384
2020-01-20T17:30:01Z
user-fp7postgrantoapilotoutputs
user-fp7-bmc
user-eu
Christine Nardini1,2,*, Valentina Devescovi1,*, Yuanhua Liu1,3,*, Xiaoyuan Zhou1,*, Youtao Lu1,* & Jennifer E. Dent1,4,*
2016-12-23
<p>Degeneration is a hallmark of autoimmune diseases, whose incidence grows worldwide. Current<br>
therapies attempt to control the immune response to limit degeneration, commonly promoting<br>
immunodepression. Differently, mechanical stimulation is known to trigger healing (regeneration) and<br>
it has recently been proposed locally for its therapeutic potential on severely injured areas. As the early<br>
stages of healing consist of altered intra- and inter-cellular fluxes of soluble molecules, we explored the<br>
potential of this early signal to spread, over time, beyond the stimulation district and become systemic,<br>
to impact on distributed or otherwise unreachable injured areas. We report in a model of arthritis in<br>
rats how stimulations delivered in the subcutaneous dorsal tissue result, over time, in the control and<br>
healing of the degeneration of the paws’ joints, concomitantly with the systemic activation of wound<br>
healing phenomena in blood and in correlation with a more eubiotic microbiome in the gut intestinal<br>
district.</p>
https://doi.org/10.1038/srep39043
oai:zenodo.org:221384
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/fp7-bmc
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
rheumatoid arthritis, wound healing, mechanotransduction
Systemic Wound Healing Associated with local sub-Cutaneous Mechanical Stimulation
info:eu-repo/semantics/article
oai:zenodo.org:159351
2020-01-20T15:32:51Z
user-fp7postgrantoapilotoutputs
user-eu
Khalsa, Jan Hari Arti
Leistner, Diana
Weller, Nadja
Darvell, Leilani I.
Dooley, Ben
2016-10-04
<p>The firing and co-firing of biomass in pulverized coal fired power plants around the world is expected to increase in the coming years. Torrefaction may prove to be a suitable way of upgrading biomass for such an application. For transport and storage purposes, the torrefied biomass will tend to be in pellet form. Whilst standard methods for the assessment of the milling characteristics of coal exist, this is not the case for torrefied materials—whether in pellet form or not. The grindability of the fuel directly impacts the overall efficiency of the combustion process and as such it is an important parameter. In the present study, the grindability of different torrefied biomass pellets was tested in three different laboratory mill types; cutting mill (CM), hammer mill (HM) and impact mill (IM). The specific grinding energy (SGE) required for a defined mass throughput of pellets in each mill was measured and results were compared to other pellet characterization methods (e.g., durability, and hardness) as well as the modified Hardgrove Index. Seven different torrefied biomass pellets including willow, pine, beech, poplar, spruce, forest residue and straw were used as feedstock. On average, the particle-size distribution width (across all feedstock) was narrowest for the IM (0.41 mm), followed by the HM (0.51 mm) and widest for the CM (0.62 mm). Regarding the SGE, the IM consumed on average 8.23 Wh/kg while CM and HM consumed 5.15 and 5.24 Wh/kg, respectively. From the three mills compared in this study, the IM seems better fit for being used in a standardized method that could be developed in the future, e.g., as an ISO standard.</p>
https://doi.org/10.3390/en9100794
oai:zenodo.org:159351
Zenodo
http://www.mdpi.com/journal/energies/special_issues/woody_biomass
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
energies, 9(10), (2016-10-04)
grindability
torrefied biomass
pellet
energy consumption
co-firing
Torrefied Biomass Pellets - Comparing Grindability in Different Laboratory Mills
info:eu-repo/semantics/article
oai:zenodo.org:44595
2020-01-20T16:27:47Z
user-fp7postgrantoapilotoutputs
user-eu
Kristóf, Endre
Doan-Xuan, Quang-Minh
Bai, Péter
Bacso, Zsolt
Fésüs, László
2015-07-27
<p>Laser-scanning cytometry is presented as a tool allowing population scale analysis of <em>ex vivo</em> human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern and functional characteristics of browning. Using this method we could validate mouse data in human samples demonstrating the effectiveness of irisin to induce “beige” differentiation of subcutaneous white adipocytes.</p>
EUR 1,165 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/srep12540
oai:zenodo.org:44595
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Scientific Reports, (2015-07-27)
Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin
info:eu-repo/semantics/article
oai:zenodo.org:1304904
2020-01-20T14:43:56Z
user-fp7postgrantoapilotoutputs
user-openaire
user-eu
Gwen Franck
2018-06-30
<p>This roadmap identifies the key goals that Research Performing Organisations, Research Libraries and Funders should aim for in order to support a sustainable environment for open access publishing in the European Research Area, together with a range of suggested concrete actions that can be undertaken.</p>
<p>This Roadmap is partially based on the report ‘ Towards a Competitive and Sustainable OA Market in Europe – A Study of the Open Access Market and Policy Environment”, which was published as deliverable D 5.3 in OpenAIRE2020 Workpackage 5 – better known as the FP7 Post-Grant Open Access Pilot. Additional suggestions and actions were crowdsourced during the workshop accompanying the end of the original Pilot period, augmented with elements gathered from the conclusions of the Pilot (final report available on Zenodo: <a href="https://doi.org/10.5281/zenodo.1304908">https://doi.org/10.5281/zenodo.1304908</a> )</p>
https://doi.org/10.5281/zenodo.1304904
oai:zenodo.org:1304904
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.1304903
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
D 5.5: Roadmap towards for a sustainable open access publishing market in Europe
info:eu-repo/semantics/report
oai:zenodo.org:23503
2020-01-20T17:41:19Z
user-fp7postgrantoapilotoutputs
user-eu
Sevenich, Robert
Reineke, Kai
Hecht, Philipp
Fröhling, Antje
Rauh, Cornelia
Schlüter, Oliver
Knorr, Dietrich
2015-07-06
<p>Much research has been conducted to comprehend the mechanisms of high pressure (HP) inactivation of spores in aqueous systems but for food model systems these information are scarce. In these systems spores can interact with ingredients which then could possibly lead to retarded or reduced inactivation, which can cause a problem for the sterilization process. The protective mechanism of a reduced <em>a</em><sub>w</sub>-value is still unclear. HP processing might prove valuable to overcome protective effects of solutes and achieve shorter process times for sterilization under HP. To gain insight into the underlying mechanisms five <em>a</em><sub>w</sub>-values (0.9, 0.92, 0.94, 0.96, 1) were adjusted with two different solutes (NaCl, sucrose). Solutions were inoculated with spores of <em>Bacillus amyloliquefaciens</em> and treated at 105, 110, and 115°C at 600 MPa. Further a thermal inactivation was conducted at the same temperatures for a comparison with the HP data. Afterward, the influence of HP high temperature treatment on the inactivation, the dipicolinic acid (DPA)-release and membrane constitution was assessed by plate count, HPLC and flow cytometry (FCM). The results show that during HP treatments sucrose and salt both have a protective effect, in which the influence of sucrose on the retarded inactivation is higher. The threshold water activities (<em>a</em><sub>w</sub>), which is 0.94, here salt and sucrose have a significant influence on the inactivation. The comparison of thermal (105–115°C) and HP and high temperature (600 MPa, 105–115°C) treated samples showed that the time needed to achieve a 4–5 log<sub>10</sub> inactivation is reduced from 45 (<em>a</em><sub>w</sub> = 1) to 75 (<em>a</em><sub>w</sub> = 0.9) min at 105°C to 3 (<em>a</em><sub>w</sub> = 1) to 15 (<em>a</em><sub>w</sub> = 0.9) minutes at 600 MPa and 105°C. The release of DPA is the rate limiting step of the inactivation and therefore monitoring the release is of great interest. The DPA-release is slowed down in high concentrated solutions (e.g., sucrose, salt) in comparison to <em>a</em><sub>w</sub> 1. Since there is a difference in the way the solutes protect the spore it could be seen as an inner spore membrane effect. Maybe as shown for vegetative microorganism the solutes can interact with membranes, e.g., the inner spore membrane. Flow cytometry (FCM) measurement data show a similar trend.</p>
USD 1425 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fmicb.2015.00689
oai:zenodo.org:23503
ean8:26217321
https://www.ncbi.nlm.nih.gov/pmc/PMC4491632
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Frontiers in Microbiology, (2015-07-06)
High pressure high temperature
reduced water activity
baroprotective effect
Bacillus amyloliquefaciens
spore inactivation
Impact of different water activities (aw) adjusted by solutes on high pressure high temperature inactivation of Bacillus amyloliquefaciens spores
info:eu-repo/semantics/article
oai:zenodo.org:582578
2020-01-20T15:20:46Z
user-fp7postgrantoapilotoutputs
user-fp7-bmc
user-eu
Durá-Gil, Juan V.
Bazuelo-Ruiz, Bruno
Moro-Pérez, David
Mollà-Domenech, Fernando
2017-05-23
<p>The literature indicates the best vibration positions and frequencies on the human body where tactile information is transmitted. However, there is a lack of knowledge about how to combine tactile stimuli for navigation. The aim of this study is to compare different vibration patterns outputted to blind people and to determine the most intuitive vibration patterns to indicate direction for navigation purposes through a tactile belt. The vibration patterns that stimulate the front side of the waist are preferred for indicating direction. Vibration patterns applied on the back side of the waist could be suitable for sending messages such as stop.</p>
https://doi.org/10.7717/peerj.3082
oai:zenodo.org:582578
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/fp7-bmc
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Blind
Navigation
Tactile device
Waist belt
Vibration
Analysis of different vibration patterns to guide blind people
info:eu-repo/semantics/article
oai:zenodo.org:44599
2020-01-20T14:59:12Z
user-fp7postgrantoapilotoutputs
user-eu
Rodríguez-Gómez, Francisco
Romero-Gil, Verónica
García-García, Pedro
Arroyo-López, Francisco Noé
Garrido-Fernández, Antonio
2015-09-23
<p>This work focuses on the persistence of the putative probiotic bacteria <em>Lactobacillus pentosus </em>TOMC-LAB2 on green Spanish-style Manzanilla olives according to different packaging conditions and storage temperatures. The lactic acid bacteria population decreased with time but the highest survival counts (and lowest yeasts) at the end of storage (8 months) were observed in plastic pouches under nitrogen atmosphere and glass jars with brine stored at 20°C. Molecular techniques showed a 100% presence of the putative probiotic bacteria in biofilms adhered to olive epidermis, while it was absent in PPB (plastic pouches with brine) and in olives stored at 7°C. No changes in NaCl, pH or combined acidity were observed during the storage except for a slight increase in titratable acidity at 20°C. The color of the fruits was stable but degraded at 20°C for olives in plastic pouches with brine.</p>
EUR 1,172 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1002/fsn3.272
oai:zenodo.org:44599
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Food Science & Nutrition, (2015-09-23)
lactic acid bacteria
packaging conditions
probiotic
table olives
yeasts
Effect of green Spanish-style Manzanilla packaging conditions on the prevalence of the putative probiotic bacteria Lactobacillus pentosus TOMC-LAB2
info:eu-repo/semantics/article
oai:zenodo.org:45192
2020-01-20T16:24:57Z
user-fp7postgrantoapilotoutputs
user-eu
Dóka, Éva
Pader, Irina
Bíró, Adrienn
Johansson, Katarina
Cheng, Qing
Ballagó, Krisztina
Prigge, Justin R.
Pastor-Flores, Daniel
Dick, Tobias P.
Schmidt, Edward E.
Arnér, Elias S. J.
Nagy, Péter
2016-01-22
<p>Hydrogen sulfide signaling involves persulfide formation at specific protein Cys residues. However, overcoming current methodological challenges in persulfide detection and elucidation of Cys regeneration mechanisms from persulfides are prerequisites for constructing a bona fide signaling model. We here establish a novel, highly specific protein persulfide detection protocol, ProPerDP, with which we quantify 1.52 ± 0.6 and 11.6 ± 6.9 μg/mg protein steady-state protein persulfide concentrations in human embryonic kidney 293 (HEK293) cells and mouse liver, respectively. Upon treatment with polysulfides, HEK293 and A549 cells exhibited increased protein persulfidation. Deletion of the sulfide-producing cystathionine-γ-lyase or cystathionine-β-synthase enzymes in yeast diminished protein persulfide levels, thereby corroborating their involvement in protein persulfidation processes. We here establish that thioredoxin (Trx) and glutathione (GSH) systems can independently catalyze reductions of inorganic polysulfides and protein persulfides. Increased endogenous persulfide levels and protein persulfidation following polysulfide treatment in thioredoxin reductase-1 (TrxR1) or thioredoxin-related protein of 14 kDa (TRP14) knockdown HEK293 cells indicated that these enzymes constitute a potent regeneration system of Cys residues from persulfides in a cellular context. Furthermore, TrxR1-deficient cells were less viable upon treatment with toxic amounts of polysulfides compared to control cells. Emphasizing the dominant role of cytosolic disulfide reduction systems in maintaining sulfane sulfur homeostasis in vivo, protein persulfide levels were markedly elevated in mouse livers where hepatocytes lack both TrxR1 and glutathione reductase (TR/GR-null). The different persulfide patterns observed in wild-type, GR-null, and TR/GR-null livers suggest distinct roles for the Trx and GSH systems in regulating subsets of protein persulfides and thereby fine-tuning sulfide signaling pathways.</p>
USD 1,500 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1126/sciadv.1500968
oai:zenodo.org:45192
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
AAAS Science Advances, 2(1), e1500968, (2016-01-22)
Life sciences
biochemistry
Proteins
hydrogen sulfide
persulfide
Thioredoxins
Glutathione system
cell signaling
ProPerDP method
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems
info:eu-repo/semantics/article
oai:zenodo.org:557001
2020-01-20T17:41:33Z
user-fp7postgrantoapilotoutputs
user-eu
Kevin Fuchs
Peter A. Henning
2017-04-24
<p>INTUITEL is a research project that was co-financed by the European Commission with the aim to advance state-of-the-art e-learning systems via addition of guidance and feedback for learners. Through a combination of pedagogical knowledge, measured learning progress and a broad range of environmental and background data, INTUITEL systems will provide guidance towards an optimal learning pathway. This allows INTUITEL-enabled learning management systems to offer learners automated, personalised learning support so far only provided by human tutors.</p>
<p>INTUITEL is – in the first place – a design pattern for the creation of adaptive e-learning systems. It focuses on the reusability of existing learning material and especially the annotation with semantic meta data. INTUITEL introduces a novel approach that describes learning material as well as didactic and pedagogical meta knowledge by the use of ontologies. Learning recommendations are inferred from these ontologies during runtime. This way INTUITEL solves a common problem in the field of adaptive systems: it is not restricted to a certain field. Any content from any domain can be annotated. The INTUITEL research team also developed a prototype system. Both the theoretical foundations and how to implement your own INTUITEL system are discussed in this book.</p>
Note: EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519503
oai:zenodo.org:557001
River Publishers
https://d-nb.info/gnd/978-87-93519-51-0 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Adaptive systems
Intelligent tutoring systems
e-learning
Blended learning
Mobile learning
Ontologies
Computers in education
Semantic technologies
Computer-Driven Instructional Design with INTUITEL
info:eu-repo/semantics/book
oai:zenodo.org:822446
2020-01-20T15:04:47Z
user-fp7postgrantoapilotoutputs
user-eu
Martin Serrano (ed.)
Nikolaos Isaris (ed.)
Hans Schaffers (ed.)
John Domingue (ed.)
Michael Boniface (ed.)
Thanasis Korakis (ed.)
2017-07-03
<p>The Internet as we know it today is the result of a continuous activity for improving network communications, end user services, computational processes and also information technology infrastructures. The Internet has become a critical infrastructure for the human-being by offering complex networking services and end-user applications that all together have transformed all aspects, mainly economical, of our lives. Recently, with the advent of new paradigms and the progress in wireless technology, sensor networks and information systems and also the inexorable shift towards everything connected paradigm, first as known as the Internet of Things and lately envisioning into the Internet of Everything, a data-driven society has been created. In a data-driven society, productivity, knowledge, and experience are dependent on increasingly open, dynamic, interdependent and complex Internet services. The challenge for the Internet of the Future design is to build robust enabling technologies, implement and deploy adaptive systems, to create business opportunities considering increasing uncertainties and emergent systemic behaviors where humans and machines seamlessly cooperate.</p>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519114
oai:zenodo.org:822446
River Publishers
https://d-nb.info/gnd/978-87-93519-12-1 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Heterogeneous Networks
Performance Modelling and Analysis
Wired Networks
Wireless Networks
Ad hoc, Sensor and Cellular Networks
Optical Networks
Next and Future Generation Internet
Building the Future Internet through FIRE
info:eu-repo/semantics/book
oai:zenodo.org:163334
2020-01-20T17:09:14Z
user-fp7postgrantoapilotoutputs
user-eu
Indrusiak, Leandro Soares (ed.)
Dziurzanski, Piotr (ed)
Singh, Amit Kumar (ed.)
2016-10-26
<p>The availability of many-core computing platforms enables a wide variety of technical solutions for systems across the embedded, high-performance and cloud computing domains. However, large scale manycore systems are notoriously hard to optimise. Choices regarding resource allocation alone can account for wide variability in timeliness and energy dissipation (up to several orders of magnitude). <em>Dynamic Resource Allocation in Embedded, High-Performance and Cloud Computing</em> covers dynamic resource allocation heuristics for manycore systems, aiming to provide appropriate guarantees on performance and energy efficiency. It addresses different types of systems, aiming to harmonise the approaches to dynamic allocation across the complete spectrum between systems with little flexibility and strict real-time guarantees all the way to highly dynamic systems with soft performance requirements. Technical topics presented in the book include: </p>
<ul>
<li>Load and Resource Models</li>
<li>Admission Control</li>
<li>Feedback-based Allocation and Optimisation</li>
<li>Search-based Allocation Heuristics</li>
<li>Distributed Allocation based on Swarm Intelligence</li>
<li>Value-Based Allocation</li>
</ul>
<p><br>
Each of the topics is illustrated with examples based on realistic computational platforms such as Network-on-Chip manycore processors, grids and private cloud environments.</p>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519077
oai:zenodo.org:163334
River Publishers
isbn:978-87-93519-08-4
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
resource allocation
scheduling
multicore
manycore
network-on-chip
real-time systems
performance predictability
Dynamic Resource Allocation in Embedded, High-Performance and Cloud Computing
info:eu-repo/semantics/book
oai:zenodo.org:1003198
2020-01-20T14:24:17Z
user-fp7postgrantoapilotoutputs
user-eu
Marije ter Wal
Paul H. Tiesinga
2017-02-09
<p>Communication between cortical sites is mediated by long-range synaptic connections. However, these connections are relatively static, while everyday cognitive tasks demand a fast and flexible routing of information in the brain. Synchronization of activity between distant cortical sites has been proposed as the mechanism underlying such a dynamic communication structure. Here, we study how oscillatory activity affects the excitability and input-output relation of local cortical circuits and how it alters the transmission of information between cortical circuits. To this end, we develop model circuits showing fast oscillations by the PING mechanism, of which the oscillatory characteristics can be altered. We identify conditions for synchronization between two brain circuits and show that the level of intercircuit coherence and the phase difference is set by the frequency difference between the intrinsic oscillations. We show that the susceptibility of the circuits to inputs, i.e., the degree of change in circuit output following input pulses, is not uniform throughout the oscillation period and that both firing rate, frequency and power are differentially modulated by inputs arriving at different phases. As a result, an appropriate phase difference between the circuits is critical for the susceptibility windows of the circuits in the network to align and for information to be efficiently transferred. We demonstrate that changes in synchrony and phase difference can be used to set up or abolish information transfer in a network of cortical circuits.</p>
USD 2116.50 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fncom.2017.00006
oai:zenodo.org:1003198
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Phase Difference between Model Cortical Areas Determines Level of Information Transfer
info:eu-repo/semantics/article
oai:zenodo.org:1291962
2020-01-20T17:39:28Z
user-fp7postgrantoapilotoutputs
openaire
user-openaire
user-eu
Gwen Franck
2018-06-18
<p>*description edited on June 18 2018*</p>
<p>Versions in reverse order of publication.</p>
<p><strong>20180618_OpenAIRE2020_FP7PostGrantPilot_data.xlsx:</strong> update of the last dataset - status of 65 publications in progress changed to 'paid'. This has no significant influence on the statistical analysis already made, as the estimated data was already processed. </p>
<p><strong>20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</strong> : These datasets contain all datasets related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot from its start in May 1st 2015 until February 28th 2018. The final report of the Pilot will be based on this dataset. </p>
<p><strong><a href="https://zenodo.org/api/files/31b3b7e0-98f6-42a0-a82f-543898dfb6bc/20170831_DatasetD5.4.xlsx?versionId=e1d01078-50fa-4997-b8b9-6efa86180f37">20170831_DatasetD5.4.xlsx</a></strong>: This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).</p>
<p>A final version will be added to this record once all remaining accounting is wrapped up (July 2018). However, we are confident that the numbers presented here show trends and averages adequately, even if the absolute numbers will still change slightly. </p>
<p>The Pilot website can be found at : https://postgrantoapilot.openaire.eu</p>
<p>To be eligible, a publication needed to comply with the following conditions: </p>
<ul>
<li>Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication P</li>
<li>ublished in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole </li>
<li>Maximum 3 publications per project</li>
<li>The funding cap is € 2000 for articles and € 6000 for monographs.</li>
</ul>
<p>Some author fees exceed this cap slightly due to currency conversion. Any other anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. </p>
<p><br>
All materials available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this datat. Feel free to ping us when you make use of it. </p>
<p>Author: Gwen Franck gwenfranckgcv@gmail.com</p>
<p>OpenAIRE on Twitter @openaire_eu</p>
<p>info@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.1291962
oai:zenodo.org:1291962
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
OpenAIRE FP7 Post-Grant Open Access Pilot: datasets and reporting
info:eu-repo/semantics/conferencePoster
oai:zenodo.org:1219084
2020-01-24T19:26:14Z
user-fp7postgrantoapilotoutputs
openaire_data
user-openaire
user-eu
Gwen Franck
2018-05-31
<p>*description edited on April 16 2018*</p>
<p>Versions in order of publication.</p>
<p><strong>20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</strong> : These datasets contain all datasets related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot from its start in May 1st 2015 until February 28th 2018. The final report of the Pilot will be based on this dataset. </p>
<p><strong><a href="https://zenodo.org/api/files/31b3b7e0-98f6-42a0-a82f-543898dfb6bc/20170831_DatasetD5.4.xlsx?versionId=e1d01078-50fa-4997-b8b9-6efa86180f37">20170831_DatasetD5.4.xlsx</a></strong>: This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).</p>
<p>A final version will be added to this record once all remaining accounting is wrapped up (July 2018). However, we are confident that the numbers presented here show trends and averages adequately, even if the absolute numbers will still change slightly. </p>
<p>The Pilot website can be found at : https://postgrantoapilot.openaire.eu</p>
<p>To be eligible, a publication needed to comply with the following conditions: </p>
<ul>
<li>Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication P</li>
<li>ublished in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole </li>
<li>Maximum 3 publications per project</li>
<li>The funding cap is € 2000 for articles and € 6000 for monographs.</li>
</ul>
<p>Some author fees exceed this cap slightly due to currency conversion. Any other anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. </p>
<p><br>
This dataset is available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute this dataset, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this dataset. Feel free to ping us when you make use of it. <br>
author: Gwen Franck gwen.franck@kb.nlOpenAIRE on Twitter @openaire_euinfo@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.1219084
oai:zenodo.org:1219084
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
OpenAIRE FP7 Post-Grant Open Access Pilot: datasets and reporting
info:eu-repo/semantics/other
oai:zenodo.org:998042
2020-01-24T19:26:12Z
user-fp7postgrantoapilotoutputs
openaire_data
user-openaire
user-eu
Gwen Franck
2017-09-27
<p>This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).The Pilot website can be found at : https://postgrantoapilot.openaire.euTo be eligible, a publication needed to comply with the following conditions: Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication Published in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole Maximum 3 publications per projectFunding cap is € 2000 for articles and € 6000 for monographs. Some author fees exceed this cap slightly due to currency conversion<br>
Any anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. <br>
This dataset is available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute this dataset, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this dataset. Feel free to ping us when you make use of it. <br>
author: Gwen Franck gwen.franck@kb.nlOpenAIRE on Twitter @openaire_euinfo@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.998042
oai:zenodo.org:998042
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
OpenAIRE FP7 Post-Grant Open Access Pilot: datasets and reporting
info:eu-repo/semantics/other
oai:zenodo.org:27294
2020-01-20T14:21:13Z
user-fp7postgrantoapilotoutputs
user-eu
Codella, Roberto
Lanzoni, Giacomo
Zoso, Alessia
Caumo, Andrea
Montesano, Anna
Terruzzi, Ileana M.
Ricordi, Camillo
Luzi, Livio
Inverardi, Luca
2015-08-09
<p>The nonobese diabetic (NOD) mouse represents a well-established experimental model analogous to human type 1 diabetes mellitus (T1D) as it is characterized by progressive autoimmune destruction of pancreatic β-cells. Experiments were designed to investigate the impact of moderate-intensity training on T1D immunomodulation and inflammation. Under a chronic exercise regime, NOD mice were trained on a treadmill for 12 weeks (12 m/min for 30 min, 5 d/wk) while age-matched, control animals were left untrained. Prior to and upon completion of the training period, fed plasma glucose and immunological soluble factors were monitored. Both groups showed deteriorated glycemic profiles throughout the study although trained mice tended to be more compensated than controls after 10 weeks of training. An exercise-induced weight loss was detected in the trained mice with respect to the controls from week 6. After 12 weeks, IL-6 and MIP-1βwere decreased in the trained animals compared to their baseline values and versus controls, although not significantly. Morphometric analysis of pancreata revealed the presence of larger infiltrates along with decreased α-cells areas in the control mice compared to trained mice. Exercise may exert positive immunomodulation of systemic functions with respect to both T1D and inflammation, but only in a stringent therapeutic window.</p>
USD 1500 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1155/2015/737586
oai:zenodo.org:27294
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Journal of Diabetes Research, 2015, (2015-08-09)
Moderate Intensity Training Impact on the Inflammatory Status and Glycemic Profiles in NOD Mice
info:eu-repo/semantics/article
oai:zenodo.org:163953
2020-01-20T15:52:00Z
user-fp7postgrantoapilotoutputs
Sabine Anne-Kristin Fraschka
Rob Wilhelmus Maria Henderson
Richárd Bártfai
2016-08-24
<p>Histones, by packaging and organizing the DNA into chromatin, serve as essential building blocks for eukaryotic life. The basic structure of the chromatin is established by four canonical histones (H2A, H2B, H3 and H4), while histone variants are more commonly utilized to alter the properties of specific chromatin domains. H3.3, a variant of histone H3, was found to have diverse localization patterns and functions across species but has been rather poorly studied in protists. Here we present the first genome-wide analysis of H3.3 in the malaria-causing, apicomplexan parasite, P. falciparum, which revealed a complex occupancy profile consisting of conserved and parasite-specific features. In contrast to other histone variants, PfH3.3 primarily demarcates euchromatic coding and subtelomeric repetitive sequences. Stable occupancy of PfH3.3 in these regions is largely uncoupled from the transcriptional activity and appears to be primarily dependent on the GC-content of the underlying DNA. Importantly, PfH3.3 specifically marks the promoter region of an active and poised, but not inactive antigenic variation (var) gene, thereby potentially contributing to immune evasion. Collectively, our data suggest that PfH3.3, together with other histone variants, indexes the P. falciparum genome to functionally distinct domains and contribute to a key survival strategy of this deadly pathogen.</p>
EUR 1165 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/srep31965
oai:zenodo.org:163953
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Histone variants
Parasite genomics
H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potential memory mark for virulence gene expression in Plasmodium falciparum
info:eu-repo/semantics/article
oai:zenodo.org:45417
2020-01-20T14:44:34Z
user-fp7postgrantoapilotoutputs
user-eu
Thomas Alexandridis
Ines Cherif
George Bilas
Waldenio G. Almeida
Isnaeni M. Hartanto
Schalk Jan van Andel
Antonio Araujo
2016-01-21
<p>Despite playing a critical role in the division of precipitation between runoff and infiltration, soil moisture (SM) is difficult to estimate at the catchment scale and at frequent time steps, as is required by many hydrological, erosion and flood simulation models. In this work, an integrated methodology is described to estimate SM at the root zone, based on the remotely-sensed evaporative fraction (Λ) and ancillary information on soil and meteorology. A time series of Terra MODIS satellite images was used to estimate SM maps with an eight-day time step at a 250-m spatial resolution for three diverse catchments in Europe. The study of the resulting SM maps shows that their spatial variability follows the pattern of land cover types and the main geomorphological features of the catchment, and their temporal pattern follows the distribution of rain events, with the exception of irrigated land. Field surveys provided <em>in situ</em> measurements to validate the SM maps’ accuracy, which proved to be variable according to site and season. In addition, several factors were analyzed in order to explain the variation in the accuracy, and it was shown that the land cover type, the soil texture class, the temporal difference between the datasets’ acquisition and the presence of rain events during the measurements played a significant role, rather than the often referred to scale difference between <em>in situ</em> and satellite observations. Therefore, the proposed methodology can be used operationally to estimate SM maps at the catchment scale, with a 250-m spatial resolution and an eight-day time step.</p>
https://doi.org/10.3390/w8010032
oai:zenodo.org:45417
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
soil water content; river basin; remote sensing; thermal infrared; MODIS
Spatial and Temporal Distribution of Soil Moisture at the Catchment Scale Using Remotely-Sensed Energy Fluxes
info:eu-repo/semantics/article
oai:zenodo.org:1168368
2020-01-20T17:26:21Z
user-fp7postgrantoapilotoutputs
Zdravkovic, Nebojsa
Milosevic, Zarko
Saveljic, Igor
Nikolic, Dalibor
Miloradovic, Vladimir
Filipovic, Nenad
2017-07-06
<p>Benign Paroxysmal Positional Vertigo (BPPV) is one of the most common vestibular disorders occuring due to the presence of basophilic particles in the semicircular canals (SCC). Three-dimensional biomechanical model of the SCC is described with full 3D fluid-structure interaction of particles, wall, cupula deformation and endolymph fluid flow. The model of the SCC with parametric defined dimension and fully 3D three SCC from patient specific 3D reconstruction is presented. Navier-Stokes equations with continuity equations described fluid flow while Arbitrary-Lagrangian Eulerian (ALE) formulation is used for mesh motion. Fluid-structure interaction for fluid coupling with cupula deformation is used. Particle tracking algorithm has been used for particle motion. Different size and number of particles with their full interaction between themselves, wall and cupula deformation are used. Velocity distribution, shear stress and force from endolymph side are presented for parametric one SCC and patient specific three SCC. All the models are used for correlation with the same experimental protocols with head moving and nystagmus eye tracking. Full fluid-structure interaction of otoconia particles, wall, cupula deflection and endolymph flow in three-dimension give more details and understanding of the pathology of the specific patient in standard clinical diagnostic and therapy procedure for BPPV.</p>
https://doi.org/10.17559/TV-20160723152540
oai:zenodo.org:1168368
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Tehnički vjesnik, 24(6), 1769-1775, (2017-07-06)
biomechanical model
BPPV
fluid-structure interaction
semi-circular canals
sedimenting particle
Three-dimensional biomechanical model of benign paroxysmal positional vertigo in the semi-circular canal
info:eu-repo/semantics/article
oai:zenodo.org:1304020
2020-01-20T17:33:21Z
user-fp7postgrantoapilotoutputs
user-eu
Luis Miguel Pinho (Editor)
Eduardo Quinones
Marko Bertogna
Andrea Marongiu
Vincent Nélis
Paolo Gai
Juan Sancho
2018-07-03
<p>Nowadays, the prevalence of computing systems in our lives is so ubiquitous that we live in a cyber-physical world dominated by computer systems, from pacemakers to cars and airplanes. These systems demand for more computational performance to process large amounts of data from multiple data sources with guaranteed processing times. Actuating outside of the required timing bounds may cause the failure of the system, being vital for systems like planes, cars, business monitoring, e-trading, etc.</p>
<p><em>High-Performance and Time-Predictable Embedded Computing</em> presents recent advances in software architecture and tools to support such complex systems, enabling the design of embedded computing devices which are able to deliver high-performance whilst guaranteeing the application required timing bounds.</p>
<p>Technical topics discussed in the book include: </p>
<ul>
<li>Parallel embedded platforms</li>
<li>Programming models</li>
<li>Mapping and scheduling of parallel computations</li>
<li>Timing and schedulability analysis</li>
<li>Runtimes and operating systems</li>
</ul>
<p>The work reflected in this book was done in the scope of the European project P‑SOCRATES, funded under the FP7 framework program of the European Commission. High-performance and time-predictable embedded computing is ideal for personnel in computer/communication/embedded industries as well as academic staff and master/research students in computer science, embedded systems, cyber-physical systems and internet-of-things.</p>
Note.-- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519695
oai:zenodo.org:1304020
eng
River Publishers
https://d-nb.info/gnd/978-87-93609-69-3 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Manycore platforms
high-performance embedded systems
parallel programming models
real-time systems
scheduling and schedulability
timing analysis
operating systems
run times
High-Performance and Time-Predictable Embedded Computing
info:eu-repo/semantics/book
oai:zenodo.org:1050361
2020-01-20T14:53:44Z
user-fp7postgrantoapilotoutputs
user-eu
Schwab, Maria
Meinke, Insa
Vanderlinden, Jean-Paul
von Storch, Hans
2017-10-04
<p>Extreme Event Attribution has raised increasing attention in climate science in the last years. It means to judge the extent to which certain weather-related extreme events have changed due to human influences on climate with probabilistic statements. Extreme Event Attribution is often anticipated to spur more than just scientific ambition. It is able to provide answers to a commonly asked questions after extreme events, namely, ‘can we blame it on climate change’ and is assumed to support decision-making of various actors engaged in climate change mitigation and adaptation. More in-depth research is widely lacking about who these actors are; in which context they can make use of it; and what requirements they have, to be able to actually apply Extreme Event Attribution. We have therefore addressed these questions with two empirical case studies looking at regional decision-makers who deal with storm surge risks in the German Baltic Sea region and heat waves in the Greater Paris area. Stakeholder interviews and workshops reveal that fields of application and requirements are diverse, difficult to explicitly identify, and often clearly associated with stakeholders' specific mandate, the hazard background, and the regional socio-economic setting. Among the considered stakeholders in the Baltic Sea region, Extreme Event Attribution is perceived to be most useful to awareness-raising, in particular for climate change mitigation. They emphasised the importance of receiving understandable information - and that, rather later, but with smaller uncertainties than faster, but with higher uncertainties. In the <em>Paris</em> case, we typically talked to people engaged in adaptation with expertise in terms of climate science, but narrowly defined mandates which is typical for the Paris-centred political system with highly specialised public experts. The interviewees claimed that Extreme Event Attribution is most useful to political leverage and public discourses. If novel information like this is not sorted out a priori, it needs to be clearly linked to impacts, preferably as monetary values lost. These examples underline the significance of conducting case-specific stakeholder mappings and consultation. Overall, our studies can thereby provide methods and exemplary empirical evidence to support developing useful services from Extreme Event Attribution for targeted groups of users.</p>
https://doi.org/10.1016/j.wace.2017.09.001
oai:zenodo.org:1050361
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Weather and Climate Extremes, (2017-10-04)
Regional decision-makers as potential users of Extreme Weather Event Attribution - Case studies from the German Baltic Sea coast and the Greater Paris area
info:eu-repo/semantics/article
oai:zenodo.org:158893
2020-01-20T15:33:28Z
user-fp7postgrantoapilotoutputs
user-eu
Fernández, Pablo
Santana, José Miguel
Ortega, Sebastián
Trujillo, Agustín
Suárez, José Pablo
Domínguez, Conrado
Santana, Jaisiel
Sánchez, Alejandro
2016-03-22
<p>Seaport monitoring and management is a significant research area, in which infrastructure automatically collects big data sets that lead the organization in its multiple activities. Thus, this problem is heavily related to the fields of data acquisition, transfer, storage, big data analysis and information visualization. Las Palmas de Gran Canaria port is a good example of how a seaport generates big data volumes through a network of sensors. They are placed on meteorological stations and maritime buoys, registering environmental parameters. Likewise, the Automatic Identification System (AIS) registers several dynamic parameters about the tracked vessels. However, such an amount of data is useless without a system that enables a meaningful visualization and helps make decisions. In this work, we present SmartPort, a platform that offers a distributed architecture for the collection of the port sensors’ data and a rich Internet application that allows the user to explore the geolocated data. The presented SmartPort tool is a representative, promising and inspiring approach to manage and develop a smart system. It covers a demanding need for big data analysis and visualization utilities for managing complex infrastructures, such as a seaport.</p>
CHF 1620 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3390/s16030417
oai:zenodo.org:158893
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Sensors, 16(3), 417, (2016-03-22)
seaport
3D visualization
FIWARE
big data
GIS
SmartPort: A Platform for Sensor Data Monitoring in a Seaport Based on FIWARE
info:eu-repo/semantics/article
oai:zenodo.org:61388
2020-01-20T17:44:23Z
user-fp7postgrantoapilotoutputs
user-eu
Taco Brandsen
2016-01-01
<p>This book addresses the practice of social innovation, which is currently very much in the public eye. New ideas and approaches are needed to tackle the severe and wicked problems with which contemporary societies are struggling. Especially in times of economic crisis, social innovation is regarded as one of the crucial elements needed to move forward. Our knowledge of its dynamics has significantly progressed, thanks to an abundance of studies on social innovation both general and sector-specific. However, despite the valuable research conducted over the past years, the systematic analysis of social innovation is still contested and incomplete. The questions asked in the book will be the following:</p>
<p>1. What is the nature of social innovations?</p>
<p>2.What patterns can be identified in social innovations emerging at the local level?</p>
<p>3.How is the emergence and spread of social innovations related to urban governance? More precisely, which conditions and arrangements facilitate and hinders social innovation?</p>
<p>We explore these questions using different types of data and methods, and studying different contexts. In particular, we focus on innovations that aim at solving problems of the young unemployed, single parents and migrants. This analysis is based on original research carried out in the period 2010-2013 in the framework of a European project with a specific empirical research strategy. Research was carried out in 20 cities in 10 different European countries.</p>
EUR 6000 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1007/978-3-319-21551-8
oai:zenodo.org:61388
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Sociology, general; Social Policy; Political Theory
Social Innovation in the Urban Context
info:eu-repo/semantics/book
oai:zenodo.org:44486
2020-01-20T16:24:39Z
user-fp7postgrantoapilotoutputs
user-eu
Butkus, Simas
Alesenkov, Aleksandr
Paipulas, Domas
Gaižauskas, Eugenijus
Melninkaitis, Andrius
Kaškelytė, Dalia
Barkauskas, Martynas
Sirutkaitis, Valdas
2015-12-17
<p>Micromachining of 1 mm thick dielectric and metallic substrates was conducted using femtosecond pulse generated filaments in water. Several hundred microjoule energy pulses were focused within a water layer covering the samples. Within this water layer, non-linear self-action mechanisms transform the beam, which enables higher quality and throughput micromachining results compared to focusing in air. Evidence of beam transformation into multiple light filaments is presented along with theoretical modeling results. In addition, multiparametric optimization of the fabrication process was performed using statistical methods and certain acquired dependencies are further explained and tested using laser shadowgraphy. We demonstrate that this micromachining process exhibits complicated dynamics within the water layer, which are influenced by the chosen parameters.</p>
CHF 1000 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3390/mi6121471
oai:zenodo.org:44486
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Micromachines, 6(12), 2010-2022, (2015-12-17)
femtosecond ablation
micromachining
light filaments
optimization
shadowgraphy
Analysis of the Micromachining Process of Dielectric and Metallic Substrates Immersed in Water with Femtosecond Pulses
info:eu-repo/semantics/article
oai:zenodo.org:1304908
2020-01-20T17:39:00Z
user-fp7postgrantoapilotoutputs
user-openaire
user-eu
Gwen Franck
2018-06-30
<p>Overview of all activities undertaken within the scope of OpenAIRE2020 WP5, based on existing reports and deliverables, blogposts, presentations and datasets, augmented with updated findings and conclusions. </p>
https://doi.org/10.5281/zenodo.1304908
oai:zenodo.org:1304908
Zenodo
https://doi.org/10.5281/zenodo.1298562
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.1304907
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
D 5.6 : Final Report on uptake and metrics
info:eu-repo/semantics/report
oai:zenodo.org:1200487
2020-01-20T17:45:23Z
user-fp7postgrantoapilotoutputs
user-eu
Niccolò Rinaldi
Michael Schröter
2018-03-16
<p>The semiconductor industry is a fundamental building block of the new economy, there is no area of modern life untouched by the progress of nanoelectronics. The electronic chip is becoming</p>
<p>an ever-increasing portion of system solutions, starting initially from less than 5% in the 1970 microcomputer era, to more than 60% of the final cost of a mobile telephone, 50% of the price of a personal computer (representing nearly 100% of the functionalities) and 30% of the price of a monitor in the early 2000’s.</p>
<p>Interest in utilizing the (sub-)mm-wave frequency spectrum for commercial and research applications has also been steadily increasing. Such applications, which constitute a diverse but sizeable future market, span a large variety of areas such as health, material science, mass transit, industrial automation, communications, and space exploration.</p>
<p><em>Silicon-Germanium Heterojunction Bipolar Transistors for mm-Wave Systems Technology, Modeling and Circuit Applications </em>provides an overview of results of the DOTSEVEN EU research project, and as such focusses on key material developments for mm-Wave Device Technology. It starts with the motivation at the beginning of the project and a summary of its major achievements. The subsequent chapters provide a detailed description of the obtained research results in the various areas of process development, device simulation, compact device modeling, experimental characterization, reliability, (sub-)mm-wave circuit design and systems.</p>
Note.- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519602
oai:zenodo.org:1200487
River Publishers
https://d-nb.info/gnd/978-87-93519-61-9 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Silicon-Germanium
Bipolar Transistors
mm-wave Systems Technology
HBT Technology
Device Simulation
Compact Modeling
mm-Wave Calibration
Reliability
Millimeter-wave circuits
Silicon-Germanium Heterojunction Bipolar Transistors for Mm-wave Systems: Technology, Modeling and Circuit Applications
info:eu-repo/semantics/book
oai:zenodo.org:165465
2024-01-04T09:49:12Z
user-fp7postgrantoapilotoutputs
user-eu
Isaacs, Talia
Trofimovich, Pavel
2016-11-14
<p>This book is open access under a CC BY licence. It spans the areas of assessment, second language acquisition (SLA) and pronunciation and examines topical issues and challenges that relate to formal and informal assessments of second language (L2) speech in classroom, research and real-world contexts. It showcases insights from assessing other skills (e.g. listening and writing) and highlights perspectives from research in speech sciences, SLA, psycholinguistics and sociolinguistics, including lingua franca communication, with concrete implications for pronunciation assessment. This collection will help to establish commonalities across research areas and facilitate greater consensus about key issues, terminology and best practice in L2 pronunciation research and assessment. Due to its interdisciplinary nature, this book will appeal to a mixed audience of researchers, graduate students, teacher-educators and exam board staff with varying levels of expertise in pronunciation and assessment and wide-ranging interests in applied linguistics.</p>
EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.21832/ISAACS6848
oai:zenodo.org:165465
Multilingual Matters
isbn:978-1-78309-683-1
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Pronunciation
Assessment
Testing
Speaking
Second Language
Language assessment
L2 pronunciation
SLA
Second Language Pronunciation Assessment
info:eu-repo/semantics/book
oai:zenodo.org:154579
2020-01-20T15:26:50Z
user-fp7postgrantoapilotoutputs
user-eu
Ash, Abigail
Francken, Michael
Pap, Ildikó
Tvrdý, Zdeněk
Wahl, Joachim
Pinhasi, Ron
2016-07-07
<p>Across much of central Europe, the <em>Linearbandkeramik</em> (LBK) represents the first Neolithic communities. Arising in Transdanubia around 5500 cal. BC the LBK spread west to the Rhine within two to three hundred years, carrying elements of a mixed agricultural economy and a relatively homogeneous material culture. Colonisation of new regions during this progress would have required economic adaptations to varied ecological conditions within the landscape. This paper investigates whether such adaptation at a local scale affected health patterns and altered the dietary habits of populations that otherwise shared a common cultural and biological origin. Analysis of non-specific stress (linear enamel hypoplasia, porotic hyperostosis, cribra orbitalia) within five LBK populations from across central Europe in conjunction with published carbon and nitrogen stable isotope data from each site revealed a high prevalence of porotic hyperostosis and cribra orbitalia in western populations that was associated with a lower animal protein intake. Hypoplastic enamel was more frequently observed in eastern populations however, and may reflect geographic differences in childhood morbidity and mortality as a result of variation in social practices relating to weaning. Local socio-economic adaptations within the LBK were therefore an important factor in the exposure of populations to non-specific stress.</p>
EUR 1,165 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/srep29458
oai:zenodo.org:154579
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Scientific Reports, 6, 29458, (2016-07-07)
archaeology
biological anthropology
bone development
Regional differences in health, diet and weaning patterns amongst the first Neolithic farmers of central Europe
info:eu-repo/semantics/article
oai:zenodo.org:23489
2020-01-20T14:45:52Z
user-fp7postgrantoapilotoutputs
user-eu
Palla, Gergely
Tibély, Gergely
Mones, Enys
Pollner, Péter
Vicsek, Tamás
2015-07-14
<p>Academic journals are the repositories of mankind’s gradually accumulating knowledge of the surrounding world. Just as knowledge is organized into classes ranging from major disciplines, subjects and fields, to increasingly specific topics, journals can also be categorized into groups using various metric. In addition, they can be ranked according to their overall influence. However, according to recent studies, the impact, prestige and novelty of journals cannot be characterized by a single parameter such as, for example, the impact factor. To increase understanding of journal impact, the knowledge gap we set out to explore in our study is the evaluation of journal relevance using complex multi-dimensional measures. Thus, for the first time, our objective is to organize journals into multiple hierarchies based on citation data. The two approaches we use are designed to address this problem from different perspectives. We use a measure related to the notion of <em>m</em>-reaching centrality and find a network that shows a journal’s level of influence in terms of the direction and efficiency with which information spreads through the network. We find we can also obtain an alternative network using a suitably modified nested hierarchy extraction method applied to the same data. In this case, in a self-organized way, the journals become branches according to the major scientific fields, where the local structure of the branches reflect the hierarchy within the given field, with usually the most prominent journal (according to other measures) in the field chosen by the algorithm as the local root, and more specialized journals positioned deeper in the branch. This can make the navigation within different scientific fields and sub-fields very simple, and equivalent to navigating in the different branches of the nested hierarchy. We expect this to be particularly helpful, for example, when choosing the most appropriate journal for a given manuscript. According to our results, the two alternative hierarchies show a somewhat different, but also consistent, picture of the intricate relations between scientific journals, and, as such, they also provide a new perspective on how scientific knowledge is organized into networks.</p>
GBP 750 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1057/palcomms.2015.16
oai:zenodo.org:23489
Zenodo
https://arxiv.org/abs/arXiv:1506.05661
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Palgrave Communications, (2015-07-14)
Hierarchical networks of scientific journals
info:eu-repo/semantics/article
oai:zenodo.org:20183
2020-01-20T14:32:22Z
user-fp7postgrantoapilotoutputs
user-eu
Komeilipoor, Naeem
Rodger, Matthew W. M.
Cesari, Paola
Craig, Cathy M.
2015-05-06
<p>To intercept a moving object, one needs to be in the right place at the right time. In order to do this, it is necessary to pick up and use perceptual information that specifies the time to arrival of an object at an interception point. In the present study, we examined the ability to intercept a laterally moving virtual sound object by controlling the displacement of a sliding handle and tested whether and how the interaural time difference (ITD) could be the main source of perceptual information for successfully intercepting the virtual object. The results revealed that in order to accomplish the task, one might need to vary the duration of the movement, control the hand velocity and time to reach the peak velocity (speed coupling), while the adjustment of movement initiation did not facilitate performance. Furthermore, the overall performance was more successful when subjects employed a time-to-contact (tau) coupling strategy. This result shows that prospective information is available in sound for guiding goal-directed actions.</p>
EUR 1600 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fnins.2015.00149
oai:zenodo.org:20183
Zenodo
https://pubmed.ncbi.nlm.nih.gov/25999805
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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perception-action coupling
sound interception
tau
interaural time difference
temporal control of movement
moving sound source
Movement and Perceptual Strategies to Intercept Virtual Sound Sources
info:eu-repo/semantics/article
oai:zenodo.org:44602
2020-01-20T16:54:03Z
user-fp7postgrantoapilotoutputs
user-eu
Yé, Maurice
Diboulo, Eric
Kagoné, Moubassira
Sié, Ali
Sauerborn, Rainer
Loukanova, Svetla
2016-01-05
<p><em><strong>Background</strong></em>: One promising way to improve the motivation of healthcare providers and the quality of healthcare services is performance-based incentives (PBIs) also referred as performance-based financing. Our study aims to explore healthcare providers’ preferences for an incentive scheme based on local resources, which aimed at improving the quality of maternal and child health care in the Nouna Health District.</p>
<p><em><strong>Design</strong></em>: A qualitative and quantitative survey was carried out in 2010 involving 94 healthcare providers within 34 health facilities. In addition, in-depth interviews involving a total of 33 key informants were conducted at health facility levels.</p>
<p><em><strong>Results</strong></em>: Overall, 85% of health workers were in favour of an incentive scheme based on the health district’s own financial resources (95% CI: [71.91; 88.08]). Most health workers (95 and 96%) expressed a preference for financial incentives (95% CI: [66.64; 85.36]) and team-based incentives (95% CI: [67.78; 86.22]), respectively. The suggested performance indicators were those linked to antenatal care services, prevention of mother-to-child human immunodeficiency virus transmission, neonatal care, and immunization.</p>
<p><em><strong>Conclusions</strong></em>: The early involvement of health workers and other stakeholders in designing an incentive scheme proved to be valuable. It ensured their effective participation in the process and overall acceptance of the scheme at the end. This study is an important contribution towards the designing of effective PBI schemes.</p>
Supplementary files available at http://www.globalhealthaction.net/index.php/gha/rt/suppFiles/29103/0.-- EUR 1,300 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.3402/gha.v9.29103
oai:zenodo.org:44602
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Global Health Action, 9(2016), (2016-01-05)
Burkina Faso
performance-based incentive
pay for performance
performance-based financing
maternal health
child health
motivation
healthcare providers
Health worker preferences for performance-based payment schemes in a rural health district in Burkina Faso
info:eu-repo/semantics/article
oai:zenodo.org:49984
2020-01-20T15:26:38Z
user-fp7postgrantoapilotoutputs
user-eu
Getino, María
Sanabria-Ríos, David J.
Fernández-López, Raúl
Campos-Gómez, Javier
Sánchez-López, José M.
Fernández, Antonio
Carballeira, Néstor M.
De la Cruz, Fernando
2015-09-01
<p>Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination of antibiotic resistance genes among human pathogens. Antibiotic resistance spread could be halted or diminished by molecules that interfere with the conjugation process. In this work, synthetic 2-alkynoic fatty acids were identified as a novel class of conjugation inhibitors. Their chemical properties were investigated by using the prototype 2-hexadecynoic acid and its derivatives. Essential features of effective inhibitors were the carboxylic group, an optimal long aliphatic chain of 16 carbon atoms, and one unsaturation. Chemical modification of these groups led to inactive or less-active derivatives. Conjugation inhibitors were found to act on the donor cell, affecting a wide number of pathogenic bacterial hosts, including <em>Escherichia</em>, <em>Salmonella</em>, <em>Pseudomonas</em>, and<em>Acinetobacter</em> spp. Conjugation inhibitors were active in inhibiting transfer of IncF, IncW, and IncH plasmids, moderately active against IncI, IncL/M, and IncX plasmids, and inactive against IncP and IncN plasmids. Importantly, the use of 2-hexadecynoic acid avoided the spread of a derepressed IncF plasmid into a recipient population, demonstrating the feasibility of abolishing the dissemination of antimicrobial resistances by blocking bacterial conjugation.</p>
USD 2,190 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1128/mBio.01032-15
oai:zenodo.org:49984
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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mBio, 6(5), e01032-15, (2015-09-01)
Synthetic Fatty Acids Prevent Plasmid-Mediated Horizontal Gene Transfer
info:eu-repo/semantics/article
oai:zenodo.org:1003196
2020-01-20T14:44:15Z
user-fp7postgrantoapilotoutputs
user-eu
Iris van de Pol
Gert Flik
Marnix Gorissen
2017-02-14
<p>Energy is the common currency of life. To guarantee a homeostatic supply of energy, multiple neuro-endocrine systems have evolved in vertebrates; systems that regulate food intake, metabolism, and distribution of energy. Even subtle (lasting) dysregulation of the delicate balance of energy intake and expenditure may result in severe pathologies. Feeding-related pathologies have fueled research on mammals, including of course the human species. The mechanisms regulating food intake and body mass are well-characterized in these vertebrates. The majority of animal life is ectothermic, only birds and mammals are endotherms. What can we learn from a (comparative) study on energy homeostasis in teleostean fishes, ectotherms, with a very different energy budget and expenditure? We present several adaptation strategies in fish. In recent years, the components that regulate food intake in fishes have been identified. Although there is homology of the major genetic machinery with mammals (i.e., there is a vertebrate blueprint), in many cases this does not imply analogy. Although both mammals and fish must gain their energy from food, the expenditure of the energy obtained is different. Mammals need to spend vast amounts of energy to maintain body temperature; fishes seem to utilize a broader metabolic range to their advantage. In this review, we briefly discuss ecto- and endothermy and their consequences for energy balance. Next, we argue that the evolution of endothermy and its (dis-)advantages may explain very different strategies in endocrine regulation of energy homeostasis among vertebrates. We follow a comparative and evolutionary line of thought: we discuss similarities and differences between fish and mammals. Moreover, given the extraordinary radiation of teleostean fishes (with an estimated number of 33,400 contemporary species, or over 50% of vertebrate life forms), we also compare strategies in energy homeostasis between teleostean species. We present recent developments in the field of (neuro)endocrine regulation of energy balance in teleosts, with a focus on leptin.</p>
USD 1615.00 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fendo.2017.00036
oai:zenodo.org:1003196
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool
info:eu-repo/semantics/article
oai:zenodo.org:164174
2020-01-20T15:46:41Z
user-fp7postgrantoapilotoutputs
user-eu
R.V. Mikhaylovskiy
E. Hendry
A. Secchi
J.H. Mentink
M. Eckstein
A. Wu
R.V. Pisarev
V.V. Kruglyak
M.I. Katsnelson
Th. Rasing
A.V. Kimel
2015-09-16
<p>Ultrafast non-thermal manipulation of magnetization by light relies on either indirect coupling of the electric field component of the light with spins via spin-orbit interaction or direct coupling between the magnetic field component and spins. Here we propose a scenario for coupling between the electric field of light and spins via optical modification of the exchange interaction, one of the strongest quantum effects with strength of 10<sup>3</sup> Tesla. We demonstrate that this isotropic opto-magnetic effect, which can be called inverse magneto-refraction, is allowed in a material of any symmetry. Its existence is corroborated by the experimental observation of terahertz emission by spin resonances optically excited in a broad class of iron oxides with a canted spin configuration. From its strength we estimate that a sub-picosecond modification of the exchange interaction by laser pulses with fluence of about 1 mJ cm<sup>−2</sup> acts as a pulsed effective magnetic field of 0.01 Tesla.</p>
EUR 3700 APC fee partially funded (2000 euros) by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/ncomms9190
oai:zenodo.org:164174
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Theoretical physics
Applied physics
Magneto-optics
Spintronics
Ultrafast optical modification of exchange interactions in iron oxides
info:eu-repo/semantics/article
oai:zenodo.org:164179
2020-01-20T17:12:22Z
user-fp7postgrantoapilotoutputs
user-eu
D. Bossini
S. Dal Conte
Y. Hashimoto
A. Secchi
R. V. Pisarev
Th. Rasing
G. Cerullo
A. V. Kimel
2016-02-05
<p>The understanding of how the sub-nanoscale exchange interaction evolves in macroscale correlations and ordered phases of matter, such as magnetism and superconductivity, requires to bridging the quantum and classical worlds. This monumental challenge has so far only been achieved for systems close to their thermodynamical equilibrium. Here we follow in real time the ultrafast dynamics of the macroscale magnetic order parameter in the Heisenberg antiferromagnet KNiF3 triggered by the impulsive optical generation of spin excitations with the shortest possible nanometre wavelength and femtosecond period. Our magneto-optical pump–probe experiments also demonstrate the coherent manipulation of the phase and amplitude of these femtosecond nanomagnons, whose frequencies are defined by the exchange energy. These findings open up opportunities for fundamental research on the role of short-wavelength spin excitations in magnetism and strongly correlated materials; they also suggest that nanospintronics and nanomagnonics can employ coherently controllable spin waves with frequencies in the 20 THz domain.</p>
EUR 3700 APC fee partially funded (2000 euros) by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1038/ncomms10645
oai:zenodo.org:164179
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Magnetic properties and materials
Nanoscience and technology
Spintronics
Macrospin dynamics in antiferromagnets triggered by sub-20 femtosecond injection of nanomagnons
info:eu-repo/semantics/article
oai:zenodo.org:45160
2020-01-20T15:27:22Z
user-fp7postgrantoapilotoutputs
user-eu
Pells, Steve
Koutsouraki, Eirini
Morfopoulou, Sofia
Valencia-Cadavid, Sara
Tomlinson, Simon R.
Kalathur, Ravi
Futschik, Matthias E.
De Sousa, Paul A.
2015-07-07
<p>Human embryonic stem cells (hESCs) undergo epigenetic changes <em>in vitro</em> which may compromise function, so an epigenetic pluripotency “signature” would be invaluable for line validation. We assessed Cytosine-phosphate-Guanine Island (CGI) methylation in hESCs by genomic DNA hybridisation to a CGI array, and saw substantial variation in CGI methylation between lines. Comparison of hESC CGI methylation profiles to corresponding somatic tissue data and hESC mRNA expression profiles identified a conserved hESC-specific methylation pattern associated with expressed genes. Transcriptional repressors and activators were over-represented amongst genes whose associated CGIs were methylated or unmethylated specifically in hESCs, respectively. Knockdown of candidate transcriptional regulators (HMGA1, GLIS2, PFDN5) induced differentiation in hESCs, whereas ectopic expression in fibroblasts modulated iPSC colony formation. Chromatin immunoprecipitation confirmed interaction between the candidates and the core pluripotency transcription factor network. We thus identify novel pluripotency genes on the basis of a conserved and distinct epigenetic configuration in human stem cells.</p>
Supporting information available at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131102#sec023.-- USD 1,350 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1371/journal.pone.0131102
oai:zenodo.org:45160
https://www.ncbi.nlm.nih.gov/pmc/PMC4495055
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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PLoS ONE, 10(7), e0131102, (2015-07-07)
DNA methylation
Small interfering RNAs
Pluripotency
Biomarkers
Gene expression
Methylation
Epigenetics
Transfection
Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State
info:eu-repo/semantics/article
oai:zenodo.org:61387
2020-01-20T13:46:00Z
user-fp7postgrantoapilotoutputs
user-eu
N. Nadif Kasri
H. van Bokhoven
W. Ba
M.M. Selten
J. van der Raadt
H. van Veen
L.-L Li
M. Benevento
A.R. Oudakker
R.S.E. Lasabuda
S.J. Letteboer
R. Roepman
R.J.A. van Wezel
M.J. Courtney
2016-02-16
<p>The molecular mechanisms that promote excitatory synapse development have been extensively studied. However, the molecular events preventing precocious excitatory synapse development so that synapses form at the correct time and place are less well understood. Here, we report the functional characterization of ARHGAP12, a previously uncharacterized Rho GTPase-activating protein (RhoGAP) in the brain. ARHGAP12 is specifically expressed in the CA1 region of the hippocampus, where it localizes to the postsynaptic compartment of excitatory synapses. ARHGAP12 negatively controls spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis. Arhgap12 knockdown results in precocious maturation of excitatory synapses, as indicated by a reduction in the proportion of silent synapses. Collectively, our data show that ARHGAP12 is a synaptic RhoGAP that regulates excitatory synaptic structure and function during development.</p>
EUR 5000 APC fee partially funded (2000 euros) by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1016/j.celrep.2016.01.037
oai:zenodo.org:61387
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function
info:eu-repo/semantics/article
oai:zenodo.org:61385
2020-01-20T15:20:39Z
user-fp7postgrantoapilotoutputs
user-eu
Myrna Keurhorst et al.
2016-07-14
<p><strong>Background:</strong> Brief interventions in primary healthcare are cost-effective in reducing drinking problems but poorly<br />
implemented in routine practice. Although evidence about implementing brief interventions is growing, knowledge<br />
is limited with regard to impact of initial role security and therapeutic commitment on brief intervention implementation.<br />
<strong>Methods: </strong>In a cluster randomised factorial trial, 120 primary healthcare units (PHCUs) were randomised to eight groups:<br />
care as usual, training and support, financial reimbursement, and the opportunity to refer patients to an internet-based<br />
brief intervention (e-BI); paired combinations of these three strategies, and all three strategies combined. To explore the<br />
impact of initial role security and therapeutic commitment on implementing brief interventions, we performed multilevel<br />
linear regression analyses adapted to the factorial design.<br />
<strong>Results: </strong>Data from 746 providers from 120 PHCUs were included in the analyses. Baseline role security and therapeutic<br />
commitment were found not to influence implementation of brief interventions. Furthermore, there were no significant<br />
interactions between these characteristics and allocated implementation groups.<br />
<strong>Conclusions: </strong>The extent to which providers changed their brief intervention delivery following experience of different<br />
implementation strategies was not determined by their initial attitudes towards alcohol problems. In future research,<br />
more attention is needed to unravel the causal relation between practitioners’ attitudes, their actual behaviour and care<br />
improvement strategies to enhance implementation science.</p>
EUR 1593.50 APC fee partially funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1186/s13012-016-0468-5
oai:zenodo.org:61385
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Brief interventions, Risky drinking, Primary healthcare, Provider influences, Implementation research
Impact of primary health care providers’ initial role security and therapeutic commitment on implementing brief interventions in managing risky alcohol consumption: a cluster randomised factorial trial
info:eu-repo/semantics/article
oai:zenodo.org:1134800
2020-01-20T13:43:36Z
user-fp7postgrantoapilotoutputs
user-eu
Galisova, Andrea
Fabryova, Eva
Sticova, Eva
Kosinova, Lucie
Jiratova, Marketa
Herynek, Vit
Berkova, Zuzana
Kriz, Jan
Hajek, Milan
Jirak, Daniel
2017-12-26
<p>The publication deals with transplantation of pancreatic islets into artificial scaffolds. By using multimodal imaging, the timing of transplantation steps was optimized in animals.</p>
https://doi.org/10.1155/2017/5418495
oai:zenodo.org:1134800
eng
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
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Contrast Media and Molecular Imaging, 2017, 13, (2017-12-26)
multimodal imaging
MRI
bioluminescence
pancreatic islets
transplantation
The Optimal Timing for Pancreatic Islet Transplantation into Subcutaneous Scaffolds Assessed by Multimodal Imaging
info:eu-repo/semantics/article
oai:zenodo.org:163311
2020-01-20T16:06:30Z
user-fp7postgrantoapilotoutputs
user-eu
Szolgayová, J.
Fuss, S.
Kaminski, T.
Scholze, M.
Gusti, M.
Heimann, M.
Tavoni, M.
2016-10-18
<p>Operationalizing a Global Carbon Observing and Analysis System (www.geocarbon.net) would provide a sound basis for monitoring actual carbon fluxes and thus getting quantities right when pricing carbon – be it in a cap-and-trade scheme or under a tax regime. However, such monitoring systems are expensive and—especially in times of economic weakness—budgets for science and environmental policy are under particular scrutiny. In this study, we attempt to demonstrate the magnitude of benefits of improved information about actual carbon fluxes. Such information enables better-informed policy-making and thus paves the way for a more secure investment environment when decarbonizing the energy sector. The numerical results provide a robust indication of a positive social value of improving carbon monitoring systems when compared to their cost, especially for the more ambitious climate policies.</p>
USD 625 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1080/23322039.2016.1239672
oai:zenodo.org:163311
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Cogent Economics & Finance, (2016-10-18)
carbon flux monitoring
carbon pricing
uncertainty
investment
decarbonization
The benefits of investing into improved carbon flux monitoring
info:eu-repo/semantics/article
oai:zenodo.org:44955
2020-01-20T16:27:20Z
user-fp7postgrantoapilotoutputs
user-eu
Laming, Sven R.
Szafranski, Kamil M.
Rodrigues, Clara F.
Gaudron, Sylvie M.
Cunha, Marina R.
Hilário, Ana
Le Bris, Nadine
Duperron, Sébastien
2015-12-28
<p>The Mediterranean Sea and adjoining East Atlantic Ocean host a diverse array of small-sized mussels that predominantly live on sunken, decomposing organic remains. At least two of these, <em>Idas modiolaeformis</em> and <em>Idas simpsoni</em>, are known to engage in gill-associated symbioses; however, the composition, diversity and variability of these symbioses with changing habitat and location is poorly defined. The current study presents bacterial symbiont assemblage data, derived from 454 pyrosequencing carried out on replicate specimens of these two host species, collected across seven sample sites found in three oceanographic regions in the Mediterranean and East Atlantic. The presence of several bacterial OTUs in both the Mediterranean Sea and eastern Atlantic suggests that similar symbiont candidates occur on both sides of the Strait of Gibraltar. The results reveal markedly different symbiotic modes in the two species. <em>Idas modiolaeformis</em> displays high symbiont diversity and flexibility, with strong variation in symbiont composition from the East Mediterranean to the East Atlantic.<em>Idas simpsoni</em> displays low symbiont diversity but high symbiont fidelity, with a single dominant OTU occurring in all specimens analysed. These differences are argued to be a function of the host species, where subtle differences in host evolution, life-history and behaviour could partially explain the observed patterns. The variability in symbiont compositions, particularly in <em>Idas modiolaeformis</em>, is thought to be a function of the nature, context and location of the habitat from which symbiont candidates are sourced.</p>
USD 1,350 APC fee funded by the EC FP7 Post-Grant Open Access Pilot.
https://doi.org/10.1371/journal.pone.0144307
oai:zenodo.org:44955
https://www.ncbi.nlm.nih.gov/pmc/PMC4692436
https://pubmed.ncbi.nlm.nih.gov/26710314
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
PLoS ONE, 10(12), e0144307, (2015-12-28)
Habitats
Mussels
Haplotypes
Cloning
Symbiosis
Sequence databases
Simpson index
Oceanography
Fickle or Faithful: The Roles of Host and Environmental Context in Determining Symbiont Composition in Two Bathymodioline Mussels
info:eu-repo/semantics/article
oai:zenodo.org:163954
2020-01-20T16:03:07Z
user-fp7postgrantoapilotoutputs
user-eu
Juliane Schmidt
Esther Janse
Odette Scharenborg
2016-05-31
<p>This study investigated whether age and/or differences in hearing sensitivity influence the perception of the emotion dimensions arousal (calm vs. aroused) and valence (positive vs. negative attitude) in conversational speech. To that end, this study specifically focused on the relationship between participants’ ratings of short affective utterances and the utterances’ acoustic parameters (pitch, intensity, and articulation rate) known to be associated with the emotion dimensions arousal and valence. Stimuli consisted of short utterances taken from a corpus of conversational speech. In two rating tasks, younger and older adults either rated arousal or valence using a 5-point scale. Mean intensity was found to be the main cue participants used in the arousal task (i.e., higher mean intensity cueing higher levels of arousal) while mean F0 was the main cue in the valence task (i.e., higher mean F0 being interpreted as more negative). Even though there were no overall age group differences in arousal or valence ratings, compared to younger adults, older adults responded less strongly to mean intensity differences cueing arousal and responded more strongly to differences in mean F0 cueing valence. Individual hearing sensitivity among the older adults did not modify the use of mean intensity as an arousal cue. However, individual hearing sensitivity generally affected valence ratings and modified the use of mean F0. We conclude that age differences in the interpretation of mean F0 as a cue for valence are likely due to age-related hearing loss, whereas age differences in rating arousal do not seem to be driven by hearing sensitivity differences between age groups (as measured by pure-tone audiometry).</p>
USD 1900 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.3389/fpsyg.2016.00781
oai:zenodo.org:163954
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
affective speech
age
hearing sensitivity
natural speech
acoustic cues
Perception of Emotion in Conversational Speech by Younger and Older Listeners
info:eu-repo/semantics/article
oai:zenodo.org:51299
2020-01-20T15:42:05Z
user-fp7postgrantoapilotoutputs
Wiesmann, Maximilian
Kiliaan, Amanda J.
Zerbi, Valerio
Jansen, Diane
Roy Haast
Lütjohann, Dieter
Broersen, Laus M.
Heerschap, Arend
2016-03-10
<p>APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD. We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment. Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice. At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice. However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss. The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice. We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype. We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging.</p>
USD 1500 APC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.1155/2016/6846721
oai:zenodo.org:51299
Zenodo
https://zenodo.org/communities/fp7postgrantoapilotoutputs
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
info:eu-repo/semantics/article
oai:zenodo.org:205913
2020-01-20T17:20:39Z
user-fp7postgrantoapilotoutputs
user-eu
Bureika, Gintautas
Boile, Maria
Pyrgidis, Christos
Kortsari, Annie
Ivanova, Natalia
Titova, Tamila
Tsykhmistro, Sergey
2016-12-14
<p>The monograph is based on the outcomes of the considerations that took place within the ambit of the project NEAR 2 – Network of European-Asian Rail Research Capacities — from 2012 to 2014. The monograph serves to bridge the gaps in knowledge and technology to improve the technical interoperability of railway, rail traffic safety regulations and risk assessment, and rolling stock maintenance system. It also analyses different railway infrastructure and identifies interoperability problems of the Eurasian Railways. This research considers three railway systems (geographical regions): first, the railways of the countries in the European Union; second, the Russian, Ukrainian, and Belarusian railways; and third, the railways of Asian countries. The monograph comprises seven chapters dealing with the particularities of rail safety regulation in different countries, technical aspects of safety and interoperability, infrastructure and signalling, track-side equipment and traffic management, locomotive slip and slide control rolling stock maintenance problems, and staff training & educational issues of Eurasian Railways. Overall concluding remarks identify future research needs and priorities that support the formulation of a relevant research agenda for the Eurasian land bridge; ascertain the common future research projects concerned with the main topics of the monograph, as well as to the combination of the interests of the Eurasian rail industry and undertakings.</p>
EUR 4,974.7 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.20334/2375-M
oai:zenodo.org:205913
Vilnius Gediminas Technical University Press
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
railway
safety
transport
Eurasian Railways
rail industry
railway infrastructure
Consolidation of technical, safety and human resources in Eurasian railway transport corridors
info:eu-repo/semantics/book
oai:zenodo.org:804888
2020-01-20T15:03:35Z
user-fp7postgrantoapilotoutputs
user-eu
Jaume Salom (ed.)
Thorsten Urbaneck (ed.)
Eduard Oró (ed.)
2017-06-09
<p>The rapid increase of cloud computing, high performance computing (HPC) and the vast growth in Internet and Social Media use have aroused the interest in energy consumption and the carbon footprint of Data Centres. Data Centres primarily contain electronic equipment used for data processing (servers), data storage (storage equipment), and communications (network equipment). Collectively, this equipment processes, stores, and transmits digital information and is known as information technology (IT) equipment.</p>
<p><em>Advanced Concepts for Renewable Energy Supply of Data Centres</em> introduces a number of technical solutions for the supply of power and cooling energy into Data Centres with enhanced utilisation of renewable energy sources in order to achieve low energy Data Centres. Because of the high energy density nature of these unique infrastructures, it is essential to implement energy efficiency measures and reduce consumption before introducing any renewable energy source. A holistic approach is used with the objective of integrating many technical solutions such as management of the IT (Information Technology) load, efficient electrical supply to the IT systems, Low-Ex air-conditioning systems, interaction with district heating and cooling networks, re-use of heat, free cooling (air, seawater, groundwater), optimal use of heat and cold storage, electrical storage and integration in smart grids.</p>
<p>This book is therefore a catalogue of advanced technical concepts that could be integrated into Data Centres portfolio in order to increase the overall efficiency and the share of renewable energies in power and cooling supply. Based on dynamic energy models implemented in TRNSYS some concepts are deeply evaluated through yearly simulations. The results of the simulation are illustrated with Sankey charts, where the energy flows per year within the subsystems of each concept for a selected scenario are shown, and graphs showing the results of parametric analysis. A set of environmental metrics (as the non-renewable primary energy) and financial metrics (CAPEX and OPEX) as well of energy efficiency metrics like the well-known PUE, are described and used to evaluate the different technical concepts.</p>
Note.- EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519411
oai:zenodo.org:804888
River Publishers
https://d-nb.info/gnd/978-87-93519-42-8 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Information technology
Data centres
IT management
Energy efficiency
Power supply
Cooling supply
Renewable energy
Environmental impact and financial metrics
Advanced Concepts for Renewable Energy Supply of Data Centres
info:eu-repo/semantics/book
oai:zenodo.org:202268
2020-01-20T17:26:20Z
user-fp7postgrantoapilotoutputs
user-eu
Rivera Andía, Juan Javier
2016-12-12
<p>Este libro admirable es el fruto maduro de un investigador que se ha ido formando y forjando en esos itinerarios de trabajo de campo y escritura de los que él da cuenta en la introducción: entre campos y ciudades, entre América y Europa, entre los Andes y las estribaciones de la Sierra madrileña, entre universi- dades y centros de distintas lenguas. Un mundo dentro de otro mundo, una realidad local dentro de la realidad global, eso es lo que presenta, a menudo con afecto, el antropólogo en esta encrucijada de itinerarios personales o colectivos de ida y vuelta. Mientras que, al fondo, parecen resonar las notas, letras y voces de unas muy poco conocidas canciones: el corpus oral de comunidades generalmente olvidadas. El libro nos conduce por los vericuetos teóricos desde una realidad conocida y presentada con infinito cuidado y dedicación, y un refinado estilo literario nada convencional.</p>
EUR 3,500 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.19238/andes2016
oai:zenodo.org:202268
Rumbo Sur
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
music
cattle handling
Latin America
La vaquerita y su canto: una antropología de las emociones
info:eu-repo/semantics/book
oai:zenodo.org:557024
2020-01-20T17:23:58Z
user-fp7postgrantoapilotoutputs
user-eu
Guillermo Payá-Vayá (ed.)
Holger Blume (ed.)
2017-04-24
<p>The European research project <strong>DESERVE</strong> (DEvelopment platform for Safe and Efficient dRiVE, 2012-2015) had the aim of designing and developing a platform tool to cope with the continuously increasing complexity and the simultaneous need to reduce cost for future embedded Advanced Driver Assistance Systems (ADAS). For this purpose, the DESERVE platform profits from cross-domain software reuse, standardization of automotive software component interfaces, and easy but safety-compliant integration of heterogeneous modules. This enables the development of a new generation of ADAS applications, which challengingly combine different functions, sensors, actuators, hardware platforms, and Human Machine Interfaces (HMI).</p>
<p>This book presents the different results of the DESERVE project concerning the ADAS development platform, test case functions, and validation and evaluation of different approaches. The reader is invited to substantiate the content of this book with the deliverables published during the DESERVE project.</p>
<p>Technical topics discussed in this book include:</p>
<ul>
<li>Modern ADAS development platforms;</li>
<li>Design space exploration;</li>
<li>Driving modelling;</li>
<li>Video-based and Radar-based ADAS functions;</li>
<li>HMI for ADAS;</li>
<li>Vehicle-hardware-in-the-loop validation systems</li>
</ul>
Note: EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.13052/rp-9788793519138
oai:zenodo.org:557024
River Publishers
https://d-nb.info/gnd/978-87-93519-14-5 (ISBN)
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Advanced Driver Assistance Systems (ADAS)
Development platforms
Driving modelling
ADAS functions
Human Machine Interfaces (HMI)
Vehicle-hardware-in-the-loop
Software/Hardware co-design
Towards a Common Software/Hardware Methodology for Future Advanced Driver Assistance Systems: The DESERVE Approach
info:eu-repo/semantics/book
oai:zenodo.org:1298562
2019-12-12T12:10:28Z
user-fp7postgrantoapilotoutputs
user-openaire
user-eu
Gwen Franck
2018-06-26
<p>*description edited on June 26 2018*</p>
<p>Versions in reverse order of publication.</p>
<p><strong>D 5.4: Second periodic report on APC uptake and metrics: </strong>the deliverable based on 20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</p>
<p><strong>20180618_OpenAIRE2020_FP7PostGrantPilot_data.xlsx:</strong> update of the last dataset - status of 65 publications in progress changed to 'paid'. This has no significant influence on the statistical analysis already made, as the estimated data was already processed. </p>
<p><strong>20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</strong> : These datasets contain all datasets related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot from its start in May 1st 2015 until February 28th 2018. The final report of the Pilot will be based on this dataset. </p>
<p><strong><a href="https://zenodo.org/api/files/31b3b7e0-98f6-42a0-a82f-543898dfb6bc/20170831_DatasetD5.4.xlsx?versionId=e1d01078-50fa-4997-b8b9-6efa86180f37">20170831_DatasetD5.4.xlsx</a></strong>: This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).</p>
<p>A final version will be added to this record once all remaining accounting is wrapped up (July 2018). However, we are confident that the numbers presented here show trends and averages adequately, even if the absolute numbers will still change slightly. </p>
<p>The Pilot website can be found at : https://postgrantoapilot.openaire.eu</p>
<p>To be eligible, a publication needed to comply with the following conditions: </p>
<ul>
<li>Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication P</li>
<li>ublished in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole </li>
<li>Maximum 3 publications per project</li>
<li>The funding cap is € 2000 for articles and € 6000 for monographs.</li>
</ul>
<p>Some author fees exceed this cap slightly due to currency conversion. Any other anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. </p>
<p><br>
All materials available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this datat. Feel free to ping us when you make use of it. </p>
<p>Author: Gwen Franck gwenfranckgcv@gmail.com</p>
<p>OpenAIRE on Twitter @openaire_eu</p>
<p>info@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.1298562
oai:zenodo.org:1298562
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
OpenAIRE FP7 Post-Grant Open Access Pilot: datasets and reporting
info:eu-repo/semantics/other
oai:zenodo.org:61088
2020-01-20T17:33:05Z
user-fp7postgrantoapilotoutputs
user-eu
Wintgens, Thomas (ed.)
Nättorp, Anders (ed.)
Elango, Lakshmanan (ed.)
Asolekar, Shyam R. (ed.)
2016-07-01
<p>Research and innovation plays an important role in providing solutions to major water challenges. Over the past decades, EU Framework Programme research funding has dedicated over EUR 1 billion to water research and Horizon 2020 will continue to support fundamental and applied research to address this complex and cross-cutting societal challenge. Water is also a very important area for international research cooperation with non-EU countries for promoting sustainable development in the context of the on-going Sustainable Development Goals discussion.<br />
Within the context of the Environment (including climate change) Theme of the FP7 Cooperation Programme, a dedicated research topic on water systems and treatment technologies to cope with water shortages in urbanised areas in India was launched in 2011. SAPH PANI “Enhancement of natural water systems and treatment methods for safe and sustainable water supply in India” was selected for funding following the evaluation of that call. Since then a more strategic cooperation on water purification and wastewater reclamation, and reuse issues was built between the European Commission and the Indian Department of Science and Technology that gave rise to a joint coordinated call for proposals in 2012 and the emergence of a strong network of European and Indian researchers working together. In this context, SAPH PANI could be considered as a precursor of such cooperation.<br />
This book summarises the key achievement of the SAPH PANI EU funded project.</p>
EUR 6,000 BPC fee funded by the EC FP7 Post-Grant Open Access Pilot
https://doi.org/10.2166/9781780408392
oai:zenodo.org:61088
IWA Publishing
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/eu
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Water resources
Water treatment
Water supply
Water scarcity
India
Aquifers
Wastewater
Water quality
Saph Pani
Natural Water Treatment Systems fo Safe and Sustainable Water Supply in the Indian Context
info:eu-repo/semantics/book
oai:zenodo.org:1291912
2020-01-24T19:26:18Z
user-fp7postgrantoapilotoutputs
openaire_data
user-openaire
user-eu
Gwen Franck
2018-06-18
<p>*description edited on June 18 2018*</p>
<p>Versions in reverse order of publication.</p>
<p><strong>20180618_OpenAIRE2020_FP7PostGrantPilot_data.xlsx:</strong> update of the last dataset - status of 65 publications in progress changed to 'paid'. This has no significant influence on the statistical analysis already made, as the estimated data was already processed. </p>
<p><strong>20180331_OpenAIRE2020_FP7PostGrantPilot_data.xlsx</strong> : These datasets contain all datasets related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot from its start in May 1st 2015 until February 28th 2018. The final report of the Pilot will be based on this dataset. </p>
<p><strong><a href="https://zenodo.org/api/files/31b3b7e0-98f6-42a0-a82f-543898dfb6bc/20170831_DatasetD5.4.xlsx?versionId=e1d01078-50fa-4997-b8b9-6efa86180f37">20170831_DatasetD5.4.xlsx</a></strong>: This dataset contains all data related to the publications funded within the OpenAIRE FP7 Post-Grant Open Access Pilot in the two first years of its run, from May 2015 until April 30, 2017. The Pilot has received an extension of 10 months. This dataset will receive an update after the Pilot has come to a definitive end (February 2018).</p>
<p>A final version will be added to this record once all remaining accounting is wrapped up (July 2018). However, we are confident that the numbers presented here show trends and averages adequately, even if the absolute numbers will still change slightly. </p>
<p>The Pilot website can be found at : https://postgrantoapilot.openaire.eu</p>
<p>To be eligible, a publication needed to comply with the following conditions: </p>
<ul>
<li>Part of FP7 project that has ended, but no longer than two years ago at the moment of acceptance of publication P</li>
<li>ublished in an Open Access Journal - we do not accept publications in so-called hybrid journals, which are journals that make individual articles Open Access but remain subscription based as a whole </li>
<li>Maximum 3 publications per project</li>
<li>The funding cap is € 2000 for articles and € 6000 for monographs.</li>
</ul>
<p>Some author fees exceed this cap slightly due to currency conversion. Any other anomalies in this dataset are to be ascribed to human error. Some adjustments might have been made on accounting level that are not reflected in this dataset. </p>
<p><br>
This dataset is available under CC0 (https://creativecommons.org/publicdomain/zero/1.0/), which means that it is dedicated to the public domain. You are free to copy, modify and distribute this dataset, even for commercial purposes, all without asking permission. Although it is not obliged, a credit to the OpenAIRE project is appreciated. At the OpenAIRE project, we are very interested in hearing how you have used this dataset. Feel free to ping us when you make use of it. <br>
author: Gwen Franck gwen.franck@kb.nlOpenAIRE on Twitter @openaire_euinfo@openaire.eu</p>
This dataset is related to OpenAIRE WP5 D5.4 (doi:10.5281/zenodo.998709)
https://doi.org/10.5281/zenodo.1291912
oai:zenodo.org:1291912
Zenodo
https://doi.org/10.5281/zenodo.998709
https://zenodo.org/communities/fp7postgrantoapilotoutputs
https://zenodo.org/communities/openaire
https://zenodo.org/communities/eu
https://doi.org/10.5281/zenodo.998041
info:eu-repo/semantics/openAccess
Creative Commons Zero v1.0 Universal
https://creativecommons.org/publicdomain/zero/1.0/legalcode
author fee
APC
open access
gold open access
open access publishing
open access funding
OpenAIRE
OpenAIRE FP7 Post-Grant Open Access Pilot: datasets and reporting
info:eu-repo/semantics/other