Role of vaccine contamination with aquaporin-4 containing chick embryo cell culture in the etiology of neuromyelitis optica spectrum disorders

Autoimmunity against aquaporin-4 (AQP4) has been associated with neuromyelitis optica spectrum disorders (NMOSD). GAD65 protein is involved in type 1 diabetes. Following an anecdotal report of type 1 diabetes diagnosis a few weeks after measles, mumps and rubella (MMR) vaccine administration, MMR vaccine contents were examined. Major proteins in the vaccine apart from the measles, mumps and rubella live viruses were chicken embryo cell culture proteins. 

 Bioinformatics analysis provide strong evidence that chicken embryo cell culture proteins in the MMR vaccine can cause the development of antibodies against chicken GAD65 which cross-react with human GAD65 protein to cause type 1 diabetes.

The same mechanism can thus result in AQP4 containing chick embryo cell culture contaminated vaccines causing NMOSD.

This is very similar to the Pandemrix vaccine causing narcolepsy.