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Bioinformatics analysis links Sudden Infant Death Syndrome to vaccine induced autoimmunity against cardiac muscle proteins
Arumugham, Vinu
Mutations in the cardiac ion channel genes KCNH2 and SCN5A have been associated with Sudden Infant Death Syndrome (SIDS) Cardiac conduction involvement in SIDS has been suspected.
Just as with mutations, autoimmunity against proteins encoded by these genes can be expected to result in dysfunction.
Protein sequence alignment analysis between vaccine antigens and cardiac proteins, show that yeast (Saccharomyces cerevisiae) contaminated Hep B, Prevnar, DTaP, and HiB vaccines can independently be significant contributors to cardiac autoimmune disease that lead to SIDS. Association of hexavalent vaccines that combine DTaP, Hep B, HiB and IPV, with spikes of SIDS occurrence therefore does not come as a surprise.
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- Publication date:
- October 30, 2017
- DOI:
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- License (for files):
- Creative Commons Attribution 4.0 International