10.5281/zenodo.3799740
https://zenodo.org/records/3799740
oai:zenodo.org:3799740
Jean Regina
Jean Regina
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Matthaios Papadimitriou-Olivgeris
Matthaios Papadimitriou-Olivgeris
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Raphaël Burger
Raphaël Burger
Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Paraskevas Filippidis
Paraskevas Filippidis
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Jonathan Tschopp1
Jonathan Tschopp1
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Florian Desgranges
Florian Desgranges
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Benjamin Viala
Benjamin Viala
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Eleftheria Kampouri
Eleftheria Kampouri
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Laurence Rochat
Laurence Rochat
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
David Haefliger
David Haefliger
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Mehdi Belkoniene
Mehdi Belkoniene
Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Carlos Fidalgo
Carlos Fidalgo
Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Antonios Kritikos
Antonios Kritikos
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Katia Jaton
Katia Jaton
Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Laurence Senn
Laurence Senn
Service of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Pierre-Alexandre Bart
Pierre-Alexandre Bart
Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Jean-Luc Pagani
Jean-Luc Pagani
Service of Intensive Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Oriol Manuel
Oriol Manuel
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Loïc Lhopitallier
Loïc Lhopitallier
Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study
Zenodo
2020
COVID-19
SARS-CoV-2
Switzerland
Mechanical Ventilation
2020-05-06
10.5281/zenodo.3799739
https://zenodo.org/communities/covid-19
Creative Commons Attribution 4.0 International
This is the dataset of the study called "Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study".
Abstract:
Background
Coronavirus disease 2019 (COVID-19) is now a global pandemic with Europe and the USA at its epicenter. Little is known about risk factors for progression to severe disease in Europe. This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.
Methods
This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.
Results
200 patients were included, of whom 37 (18·5%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation in males (3.26, 1.21-9.8; p=0.025), in patients who presented with a qSOFA score ≥2 (6.02, 2.09-18.82; p=0.001), with bilateral infiltrate (5.75, 1.91-21.06; p=0.004) or with a CRP of 40 mg/l or greater (4.73, 1.51-18.58; p=0.013).
Conclusions
This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.