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Head-to-head comparison of available commercial antibodies against Midkine by immunoblot (Western blot) and immunoprecipitation on total cell lysates and conditioned media. The workflow and data collected in this study was used to create an article published on F1000, DOI: 10.12688/f1000research.130587.1.
\n\nWork reported in this report was supported in part by the Emory-Sage-SGC TREAT-AD center established by the National Institutes of Aging under award number U54AG065187.
", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2021-11-04", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Midkine" }, { "subject": "midkine" }, { "subject": "MDK" }, { "subject": "mdk" }, { "subject": "P21741" }, { "subject": "antibody characterization" }, { "subject": "antibody validation" } ], "title": "Antibody Characterization Report for Midkine" }, "parent": { "access": { "owned_by": { "user": 203156 } }, "communities": { "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2021-11-09T00:02:01.737379+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "202e8f59-215b-490f-a257-f0273d2ec041", "links": {}, "metadata": { "curation_policy": "This community accepts work generated by the TREAT-AD consortium and collaborators.
\r\n", "page": "The overarching purpose of the TREAT-AD program is to improve, diversify and reinvigorate the Alzheimer’s disease (AD) drug development pipeline by accelerating the characterization and experimental validation of next generation therapeutic targets and integrating the targets into drug discovery campaigns. In addition, this program aims to de-risk potential therapeutics to the point that industry will invest in them, accelerating the delivery of new drugs to AD patients. To this end, the funded Centers (Emory-Sage-SGC and IUSM-Purdue) will 1) design, develop and disseminate tools that support target enabling packages (TEPs) for the experimental validation of novel, next generation therapeutic targets, including those emanating from the NIA-funded, target discovery programs such as Accelerating Medicines Partnership-Alzheimer’s Disease (AMP-AD), and 2) initiate early stage drug discovery campaigns against the enabled targets. Central to this initiative is the open-access, rapid dissemination of data, methods, and computational and experimental tools generated by the Centers to all qualified researchers for their use in advancing AD drug discovery and AD disease biology.
\r\n\r\nFor more information, please visit our website: https://treatad.org/.
\r\n\r\nFor a catalog of resources, please visit the AD Knowledge Portal Target Enabling Resources
\r\n\r\n", "title": "TREAT-AD: TaRget Enablement to Accelerate Therapy Development for AD" }, "revision_id": 0, "slug": "treatad", "updated": "2021-11-10T22:20:26.509186+00:00" }, { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2021-03-13T19:45:11.575007+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "dc7d9bf2-d761-453f-9ae6-9f14a5a5e209", "links": {}, "metadata": { "curation_policy": "
YCharOS's team is entitled to upload antibody characterization studies.
\r\n", "page": "YCharOS' mission is to conduct antibody characterization studies for every human protein. Antibody characterization reports are being uploaded in this community.
\r\n\r\nYCharOS follows an antibody characterization pipeline published in 2019 in eLife: https://elifesciences.org/articles/48363
\r\n\r\nFor more information, please visit our webpage:
\r\n\r\nhttps://ycharos.com/
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