Published June 3, 2023
| Version v1
Dataset
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Asp138 orientation correlates with ligand subsite occupancy.
Description
This directory contains all files required to plot Asp138 orientation against ligand subsite occupancy across all mouse AMCase structures presented in Figure 3 of Díaz et al. (2023).
Data was analyzed using Graphpad Prism. Figures were compiled using Adobe Illustrator.
Figures
- contains PDFs of the occupancy at sugar-binding subsite across all mouse AMCase models presented in Díaz et al., (2023).
Occupancy.pzfx
- contains raw data and plots of ligand occupancy, and Asp138 active conformation occupancy.
Contact:
Roberto Efraín Díaz, robertoefrain.diaz@ucsf.edu
James Fraser, jfraser@fraserlab.com
Files
Asp138 active conf. occupancy.zip
Files
(957.7 kB)
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md5:16cf6aea754e4e592aa965ac118aac63
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Additional details
Funding
- Targeting chitin in fibrotic lung disease 5R01HL148033-03
- National Institutes of Health
References
- Díaz, Roberto Efraín et al. (2023). Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.