Proposed catalytic mechanism of mAMCase.
- 1. University of California, San Francisco
Description
This directory contains all files required to analyze the proposed catalytic mechanism of mouse AMCase at pH 2.0 and 6.5 presented in Figure 6 in the manuscript Díaz et al. (2023).
Structure models were analyzed using PyMOL. Figures were compiled using PerkinElmer ChemDraw and Adobe Illustrator.
Files included in this directory:
Figures
- contains ChemDraw file for the proposed catalytic mechanism schematic, PNGs of each step of the proposed catalytic mechanism at pH 2.0 and 6.5, and a GIF of the entire proposed catalytic mechanism at pH 2.0 and 6.5.
PyMOL
- contains all structure models, PyMOL script, and PyMOL session used to generate Figure 6.
Contact:
Roberto Efraín Díaz, robertoefrain.diaz@ucsf.edu
James Fraser, jfraser@fraserlab.com
Files
Catalytic Mechanism.zip
Files
(15.0 MB)
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Additional details
Funding
- Targeting chitin in fibrotic lung disease 5R01HL148033-03
- National Institutes of Health
References
- Díaz, Roberto Efraín et al. (2023). Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase.