Channel information at: T = 34.0 degC, E_rev = 0 mV, [Ca2+] = 0.00043 mM

na

na.channel.nml

Ion: na

g = gmax * m3 * h


Sodium channel, Hodgkin-Huxley style kinetics. WARNING: Global parameter "vshift" from modfile has not been implemented. Comments from original mod file: 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines(michael.hines@yale.e) and Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal 11 Jan 2007 Glitch in trap where (v/th) was where (v-th)/q is. (thanks Ronald van Elburg!) na.mod Sodium channel, Hodgkin-Huxley style kinetics. Kinetics were fit to data from Huguenard et al. (1988) and Hamill et al. (1991) qi is not well constrained by the data, since there are no points between -80 and -55. So this was fixed at 5 while the thi1,thi2,Rg,Rd were optimized using a simplex least square proc voltage dependencies are shifted approximately from the best fit to give higher threshold Author: Zach Mainen, Salk Institute, 1994, zach@salk.edu


na steady state na time course

kca

kca.channel.nml

Ion: k

g = gmax * n


Comment from original mod file: Calcium-dependent potassium channel, Based on Pennefather (1990) -- sympathetic ganglion cells, taken from Reuveni et al (1993) -- neocortical cells Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu


kca steady state kca time course

km

km.channel.nml

Ion: k

g = gmax * n


Potassium channel, Hodgkin-Huxley style kinetics Comments from original mod file: 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines(michael.hines@yale.e) and Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal km.mod Potassium channel, Hodgkin-Huxley style kinetics Based on I-M (muscarinic K channel) Slow, noninactivating Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu


km steady state km time course

kv

kv.channel.nml

Ion: k

g = gmax * n


Potassium channel, Hodgkin-Huxley style kinetics Comments from original mod file: 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines(michael.hines@yale.e) and Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal kv.mod Potassium channel, Hodgkin-Huxley style kinetics Kinetic rates based roughly on Sah et al. and Hamill et al. (1991) Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu


kv steady state kv time course

it

it.channel.nml

Ion: ca

g = gmax * m2 * h


T-type Ca channel WARNING: Global parameter "vshift" from modfile has not been implemented. Comments from original mod file: T-type Ca channel ca.mod to lead to thalamic ca current inspired by destexhe and huguenrd Uses fixed eca instead of GHK eqn changed from (AS Oct0899) changed for use with Ri18 (B.Kampa 2005)


it steady state it time course

ca

ca.channel.nml

Ion: ca

g = gmax * m2 * h


HVA Ca Current WARNING: Global parameter "shift" from modfile has not been implemented. Comments from original mod file 26 Ago 2002 Modification of original channel to allow variable time step and to correct an initialization error. Done by Michael Hines(michael.hines@yale.e) and Ruggero Scorcioni(rscorcio@gmu.edu) at EU Advance Course in Computational Neuroscience. Obidos, Portugal ca.mod Uses fixed eca instead of GHK eqn HVA Ca current Based on Reuveni, Friedman, Amitai and Gutnick (1993) J. Neurosci. 13: 4609-4621. Author: Zach Mainen, Salk Institute, 1994, zach@salk.edu


ca steady state ca time course