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Topical chicken protein to treat type 1 diabetes? The immunological basis explained ...

Arumugham, Vinu

Peanut protein patch applied to HEALTHY skin is a treatment for peanut allergy. One of the ways peanut protein applied to skin works, is the generation of regulatory T cells (Tregs) specific to peanut. Tregs regulate/moderate the immune system's reaction to peanut exposure.
One of the causes for type 1 diabetes (T1D) is a reduction in the number of Tregs in the pancreas. This allows CD8+ T cells to attack the islet cells, unrestrained, causing T1D.

Chicken protein contaminated vaccines are the most likely source of the proteins that train the CD8+ T cells to attack the islet cells. We need chicken protein specific Tregs to restrain them.
The potential solution is to create chicken protein specific Tregs by topical chicken protein.

Tregs are trained to home to a part of the body. Eating/drinking chicken protein generates Tregs that home to the gut.
Topical chicken protein generates Tregs that home to the skin. The CD8+ T cells that attack islet cells are trained to home to the skin. But it turns out the pancreas attract these cells by producing the same chemical attractant as the skin. Therefore skin homing Tregs produced by topical chicken protein will also home to the pancreas just like the CD8+ T cells.

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