Ana Valério-Bolas https://orcid.org/0000-0002-0273-4353, Mafalda Meunier, Joana Palma-Marques https://orcid.org/0000-0001-6639-1495, João Durões-Oliveira https://orcid.org/0009-0006-0585-5050, Marta Monteiro, Ana Armada https://orcid.org/0000-0001-5066-9982, Claudia Moreno https://orcid.org/0000-0002-6948-9823 , Armanda Rodrigues https://orcid.org/0000-0003-4261-3879, Graça Alexandre-Pires, Isabel Pereira da Fonseca https://orcid.org/0000-0002-6632-1224, Gabriela Santos-Gomes https://orcid.org/0000-0001-9264-3887

Dendritic cells (DCs) possess the capacity to initiate and regulate both innate and adaptive immune responses. Until being exposed to stimuli, such as pathogens and pro-inflammatory cytokines, DCs are in an immature and inactivated state. Conventional DCs are classified into two major subsets, migratory CD1c+DCs (cDCs) and lymph node resident CD141+DCs. cDCs are recognized for
activating CD4⁺ and CD8⁺ T cells by antigen cross-presentation and produce type I IFN, which regulates immune system activity. Thus, DCs-immune teaching represents an exciting branch of immunotherapy aiming to boost the immune response against parasites, such as Leishmania infantum and Trypanosoma cruzi parasites. Moreover, cell-based therapies, using ex-vivo DCs
generated from blood monocyte precursors (moDCs) or directly obtained from peripheral blood and pulsed with pathogen antigens to induce CD4+ and CD8+ T cell-mediated immunity are being exploited for prophylactic and clinical intervention, as they have a low toxicity risk and hold the potential of activating other immune modulators.

This repository includes gene expression data sets of receptors and immune mediators of moDCs.

Collection of DogIPM community  includes datasets of DCs gene expression.